预注异丙嗪对小鼠足底皮下注射甲醛的超前镇痛效应  

Preemptive analgesic effects of pre-injection of promethazine on the nociception induced by subcutaneous injection of formalin in the sole of mouse paw

作　　者：张松[1] 方昕[1] 张锋[1] 李丽[1] 周瑶[1] 胡凯华[1] 戚英杰[1] 王丹[2] 

机构地区：[1]徐州医学院麻醉学院,2006级2班江苏徐州221004 [2]徐州医学院麻醉药理学教研室

出　　处：《徐州医学院学报》2010年第7期453-454,共2页Acta Academiae Medicinae Xuzhou

基　　金：江苏省高校自然科学基础研究项目(09KJB320019)

摘　　要：目的研究异丙嗪是否具有超前镇痛作用。方法将小鼠按分层随机区组设计分成3组:异丙嗪(5mg.kg-1)+哌替啶(20 mg.kg-1)组(P+D组)、哌替啶(40 mg.kg-1)组(D组)、生理盐水组(NS组),每组10只。以甲醛法分别观察各组小鼠注射甲醛后5 min内的舔足时间。结果 P+D组和D组小鼠舔足时间均显著低于NS组(P<0.01),而两组间的差异无统计学意义(P>0.05)。结论异丙嗪具有超前镇痛作用。Objective To investigate whether promethazine has the effect of preemptive analgesia.Methods 30 mice were divided into three groups by stratified random block design（n=10,each）： promethazine（5 mg·kg-1） ＋ pethidine（20 mg·kg-1） group（P＋D group）,pethidine（40 mg·kg-1） group（D group） and normal saline group（NS group）.In the formalin test,subcutaneous injection of formalin was administered in the sole of mouse paw and the duration of paw-licking within 5 min was observed in each mouse.Result The duration of paw-licking was shorter in P＋D group or D group than in the NS group（P0.01）,while there was no statistical difference between P＋D group and D group（P0.05）.Conclusion Promethazine has the effect of preemptive analgesia.

关 键 词：异丙嗪 超前镇痛 甲醛 

分 类 号：R614.2[医药卫生—麻醉学]