间歇低氧训练对SD大鼠心肌肌球蛋白重链表达的影响  

Effects of intermittent hypoxic training on the expression of myosin heavy chain in myocardial of SD rats

作　　者：刘旭东[1] 周里[1] 

机构地区：[1]西安体育学院,陕西西安710068

出　　处：《山东体育学院学报》2010年第7期42-45,共4页Journal of Shandong Sport University

基　　金：陕西省自然科学基础研究项目(2009JM4004-4)

摘　　要：目的:观察在间歇低氧及游泳运动的影响下,SD大鼠心肌细胞肌球蛋白重链α-MHC、β-MHC两种异构型表达的变化,探讨间歇低氧训练对心肌功能影响的可能分子机制。方法:将128只SD大鼠随机分成对照组、间歇低氧训练组、游泳训练组及间歇低氧+游泳训练组,经过4周的训练,采用SDS-PAGE法观察SD大鼠心肌细胞肌球蛋白重链α-MHC、β-MHC表达的变化。结果:间歇低氧及游泳训练可引起α-MHC表达不同程度的上调,同时β-MHC表达不同程度的下调。结论:在间歇低氧及运动性机械刺激作用的过程中,心肌细胞通过上调α-MHC和下调β-MHC的表达,来适应环境氧分压降低的变化和运动刺激的作用。Objective ： To study the effects of intermittent hypoxic training and swimming training on the expression of α - MHC,β -MHC in myocardial of SD rats. Method： 128 SD rats were randomly divided into four groups, bland control group, hypoxic groups, swimming groups and hypoxic ＋ swimming group. After 4 weeks intermittent hypoxic training and swimming training, it used SDS - PAGE to detect the expressions of α - MHC, β - MHC in myocardial of SD rats. Results ： Both intermittent hypoxic training and swimming training can up - regulat regulate the expression of β - MHC in some extent. Conclusion： In the process ming training, myocardial adapted to the decrease of partial pressure of oxygen e the expression of α - MHC and down - of intermittent hypoxic training and swimming training by readjusting the expressions of MHC.

关 键 词：间歇低氧训练 肌球蛋白重链 心肌 游泳训练 

分 类 号：G804.7[文化科学—运动人体科学]