氯虫酰胺的合成工艺改进  

Process Improvement of the Synthesis of Chlorantraniliprole

作　　者：郭长彬[1] 唐朝军[1] 张亮亮[1] 吕超[1] 赵欣[1] 

机构地区：[1]首都师范大学化学系,北京100048

出　　处：《广州化工》2010年第7期101-102,共2页GuangZhou Chemical Industry

摘　　要：氯虫酰胺是鱼尼丁受体活化剂类广谱杀虫剂。本文以2,3-二氯吡啶和2-氨基-3-甲基苯甲酸为原料,经肼解、合环、溴代、芳构化、水解、氯代、酰胺化等七步反应合成了氯虫酰胺,总收率为16.4%,目标物和所有中间体的结构均经1H NMR表征。Chlorantraniliprole was a broad-spectrum insecticide acting as ryanodine receptor activator.Chlorantraniliprole was synthesized,with total yield of 16.4%,via the reactions of hydrazinolysis,ring condensation,bromination,aromatization,hydrolysis,chlorination and amidation,taking 2,3-dichloropyridine and 2-amino-3-methylbenzoic acid as raw materials.Chlorantraniliprole and all intermediates were structurally confirmed by 1H NMR.

关 键 词：氯虫酰胺 杀虫剂 工艺改进 一瓶反应 

分 类 号：TQ450.1[化学工程—农药化工]