利拉萘酯合成工艺改进  

Improved Process for Liranaftate Synthesis

作　　者：石庆东 杨志和[1] 李卫民[1] 张端云[1] 王凯[1] 

机构地区：[1]河南天方药业股份有限公司,河南驻马店463000

出　　处：《广州化工》2010年第7期129-130,共2页GuangZhou Chemical Industry

摘　　要：改进了利拉萘酯的合成方法。以2,6-二氯吡啶为起始原料,经醚化胺化、硫酰化和缩合反应合成利拉萘酯,总收率82%。目标物的结构经IR、HNMR、MS等方法确证。改进后的工艺具有原料易购,反应温和,操作简便,质量稳定可靠,收率高等特点,适宜工业规模生产。The improved process for liranaftate synthesis was introduced.The target compound was synthesized from 2,6-dichloro-pyridine as the starting material via steps including etherification,mination,sulfur acylation and condensation,with a total yield of 82%.The structure of the target compound was conformed by IR,HNMR,and MS.The improved process was easy to purchase raw materials,mild reaction,simple operation,stable quality,reliable,and high yield,which was suitable for industrial-scale production.

关 键 词：利拉萘酯 工艺改进 抗真菌药 化学合成 

分 类 号：TQ560.6[化学工程—炸药化工]