钌(Ⅱ)多吡啶配合物作为DNA分子光开关研究进展(英文)  

Functionalized ruthenium(Ⅱ) polypyridyl complexes as DNA molecular light switches

作　　者：张黔玲[1] 史菊英[1] 刘剑洪[1] 王明良[1] 

机构地区：[1]深圳大学化学与化工学院深圳市功能高分子重点实验室,深圳508060

出　　处：《深圳大学学报（理工版）》2010年第3期253-259,共7页Journal of Shenzhen University(Science and Engineering)

基　　金：supported by the National Natural Science Foundation of China (20601019, 20804023)~~

摘　　要：阐述八面体钌(Ⅱ)多吡啶配合物的光物理和光化学性质.当钌(Ⅱ)多吡啶配合物与DNA作用时,配合物的荧光会发生显著变化,使其能够作为DNA的敏感探针.介绍八面体多吡啶钌(Ⅱ)配合物在DNA结构探针、DNA分子光开关及DNA序列选择断裂试剂等生物无机化学领域的研究进展.评述单核及双核钌(Ⅱ)多吡啶配合物作为DNA分子光开关方面的研究前景与方法,对深入研究新型高效的DNA分子光开关提出建议和看法.Octahedral ruthenium （Ⅱ ） polypyridyl complexes have rich photophysical and photochemical properties. Their luminescence can be perturbed upon binding to DNA, providing sensitive probes for double stranded DNA in solution. In recent years, these complexes have been widely used as non-radioactive DNA molecular light switches. In this paper, we present research progress on the DNA molecular light switch function of some different mononuclear and binuclear ruthenium （ Ⅱ ） polypyridyl complexes, which may make some contribution to the further development of novel molecular light switches for DNA with higher efficiency.

关 键 词：钌(Ⅱ)多吡啶配合物 脱氧核糖核酸(DNA) 分子光开关 双核 过渡金属离子 核酸分子识别 

分 类 号：O614.8[理学—无机化学] Q523[理学—化学]