ICAM-1系统在异位性皮炎发病中的意义  

THE ROLE OF ICAM 1 SYSTEM IN PATHOGENESIS OF ATOPIC DERMATITIS

作　　者：尹兴平[1] 唱文娟[1] 张开明[1] 

机构地区：[1]太原市中心医院

出　　处：《山西医药杂志》1999年第2期98-99,共2页Shanxi Medical Journal

摘　　要：为了解ＩＣＡＭ－１系统在异位性皮炎（ＡＤ）发病中的作用，采用ＥＬＩＳＡ和免疫组化技术对ＡＤ患者的血清、皮损、外周血ＰＢＭＣ的ｓＩＣＡＭ－１含量及ＩＣＡＭ－１表达进行了综合研究。结果显示：①ＡＤ患者血清ｓＩＣＡＭ－１含量显著高于对照组，而每１００个ＰＢＭＣ中ＩＣＡＭ－１表达阳性细胞数两组间无明显差异；②１１例皮损中ＩＣＡＭ－１表达呈强阳性者共６例，主要位于基底层角蛋白细胞和真皮浸润的炎症细胞表面，９例对照标本仅２例基底角蛋白细胞呈弱阳性。提示ＡＤ发病与ＩＣＡＭ－１系统有密切的关系。To explore the role of ICAM 1 system in the pathogenesis of atopic dermatitis (AD),the level of sICAM 1 and expression of ICAM 1 on AD skin lesions and the isolated peripheral blood mononucleus cells (PBMC) were examined by ELISA and immunohistochemistry,respectively.The results are as follows:①The level of sICAM 1 in AD was markedly higher than that in controls,but there was no significant numerical difference of PBMC with positive ICAM 1 expression between the two groups;②ICAM 1 was strongly expressed in 6 lesions of 11 AD,especially on the surface of keratinocytes in epidermal basal strata and of inflammatory cells locally infiltrating in dermis,however,only 2 of the 9 controls had a weak ICAM 1 expression on their basal keratinocytes.The study suggested the change of ICAM 1 system plays some part in the pathogenesis of AD.

关 键 词：异位性皮炎 ICAM-1 SICAM-1 发病机制 

分 类 号：R758.290.2[医药卫生—皮肤病学与性病学]