异丙酚或七氟醚诱导对小儿Q-T间期的影响  

Effect of Induction by Sevoflurane or Propofol on Q-T Interval in Children

作　　者：咸云淑[1] 徐纳新[1] 董心童[1] 

机构地区：[1]北京大学深圳医院麻醉科,深圳市518036

出　　处：《实用心脑肺血管病杂志》2010年第7期867-868,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的评估异丙酚或七氟醚诱导对小儿Q-T间期的影响。方法 30例行择期手术小儿患者ASAⅠ～Ⅱ级,年龄2～7岁,术前心电图无异常,随机分为两组,S组(七氟醚组15例),P组(异丙酚组15例)。分别于麻醉前、诱导后1min、5min、10min行12导联心电图检查,测定Q-T间期,通过Bazett公式计算Q-TC。结果诱导后七氟醚组Q-T间期和Q-TC显著延长(P<0.05);异丙酚组Q-T间期有降低趋势,但无统计学意义(P>0.05)。结论七氟醚使小儿Q-T间期延长,异丙酚对小儿Q-T间期无明显影响。Objective To observe the effect of sevoflurane or propofol on Q-TC interval during induction in children.Methods 30 children with normal electrocardiogram（ECG） were randomly devided into 2 groups：group S（n=15）,induced by 8% sevoflurane;group P（n=15）,induced by propofol 2.5mg/kg.Q-T interval was measured before induction and 1,5,10min after induction,Q-TC interval corrected by HR calculated according to Bazett′s formula：QTc=QT/vR-R.Results There was significant difference between the two groups in Q-T interval and Q-Tc interval 1,5,10min（P0.05） after induction.For group S,there was significant change in Q-T interval and Q-TC interval.Conclusion Propolfol has no effect on Q-T interval in chiildren;but sevoflurane prolong the rate-corrected Q-T intervalation.

关 键 词：七氟醚 异丙酚 小儿 

分 类 号：R540.41[医药卫生—心血管疾病]