3,6-[二甲氨基]-二苯骈碘杂六环枸橼酸盐对离体豚鼠心脏钙反常的保护作用  

PROTECTIVE EFFECT OF 3, 6-DIMETHAMIDODIBENZOPYRIDONIUM CITRATE (IHC-65) ON CALCIUM PARADOX IN ISOLATED GUINEA PIG HEARTS

作　　者：孙良起[1] 袁素芬[2] 邱培伦[3] 马宏锐 

机构地区：[1]现在解放军第150医院检验科,洛阳471031 [2]生物化学教研室,西安710061 [3]西安医科大学药理教研室

出　　处：《西安医科大学学报》1999年第1期1-4,26,共5页Journal of Xi'an Medical University(Chinese)

基　　金：国家自然科学基金!No389708392

摘　　要：观察了ＩＨＣ－６５对离休豚鼠心脏钙反常的影响，结果表明：ＩＨＣ－６５可使冠脉流出液中ＣＰＫ和蛋白质漏出量比钙反常组明显减少。同时升高心肌ＣＰＫ和ＧＳＨｐｘ活性，减少ＭＤＡ的生成。说明ＩＨＣ－６５对离休豚鼠心脏钙反常有保护作用。其机制可能与抑制脂质过氧化作用有关。The aim of the present study to assess the protective effect of IHC-65 on calcium paradox in the isolated guinea pig hearts. The resultsshowed that in the treatment with IHC-65 group,the protein leakage and creatine phosphokinase(CPK ) release decreased during reper fusion andIHC-65 can attentuate the decrease in myocardial activity of CPK and glutathione peroxidase (GSHpx)also reduce the generation of malonaldehyde (MDA)in myocardium. Comparison with the calcium para-dox group, these changes were statistically significant. The results of the present study suggests thatcalcium paradox is attenuated by IHC-65 in the isolated guinea pig hearts. The protective mechanismmay be associated with the inhibition of lipid peroxi-dation.

关 键 词：心肌保护 豚鼠 IHC-65 钙反常 CPK GSHPX MDA 

分 类 号：R542.2[医药卫生—心血管疾病] R972[医药卫生—内科学]