慢性心力衰竭患者急性时相反应蛋白与心功能的相关性研究  

Correlation research between acute-phase proteins and cardiac function in patients with chronic heart failure

作　　者：李龙平[1] 王新华[1] 胡景云[1] 

机构地区：[1]中南大学湘雅医学院益阳临床学院,湖南益阳413000

出　　处：《检验医学》2010年第7期533-535,共3页Laboratory Medicine

摘　　要：目的探讨慢性心力衰竭（CHF）患者急性时相蛋白变化及其与心功能的关系。方法分别检测80例心功能Ⅰ-Ⅳ级的CHF患者（CHF组）和50名正常健康体检者（对照组）的血浆纤维蛋白原（Fib）、血清唾液酸（SA）、C反应蛋白（CRP）和左心室射血分数（LVEF）水平。根据心功能分级水平将80例CHF患者分为心功能Ⅰ-Ⅱ组（52例）和心功能Ⅲ-Ⅳ组（28例）,比较2组患者血浆Fib、血清SA和CRP水平。结果CHF组患者Fib、SA和CRP水平明显高于对照组（P均〈0.01）,LVEF明显低于对照组（P〈0.01）。LVEF与Fib（r=0.122,P〉0.05）、SA（r=-0.093,P〉0.05）和CRP（r=0.128,P〉0.05）均无相关性。心功能Ⅲ-Ⅳ组患者血浆Fib和血清CRP水平明显高于心功能Ⅰ-Ⅱ组（P〈0.01）,但血清SA无明显差异（P〉0.05）。结论CHF患者急性时相反应蛋白与心功能密切相关,但与LVEF无相关性。Objective To investigate the relationship between acute-phase proteins and cardiac function in patients with chronic heart failure（CHF）.Methods Plasma fibrinogen（Fib）,serum sialic acid（SA）,C reactive protein（CRP） and left ventricular ejection fraction（LVEF） values were measured in 80 patients with CHF Ⅰ-Ⅳ（CHF group） and 50 healthy controls（control group）.According to their cardiac function,all 80 patients with CHF were classified into the group Ⅰ-Ⅱ（52 cases） and the group Ⅲ-Ⅳ（28 cases）,and their levels of Fib,SA,and CRP were compared.Results The levels of Fib,SA and CRP in the CHF group were considerably higher than those in the control goup（P〈0.01）,while the LVEF level was markedly lower（P〈0.01）.There were no significant correlations between LVEF and Fib（r=0.122,P〉0.05）,SA（r=-0.093,P〉0.05） and CRP（r=0.128,P〉0.05）.The plasma Fib and serum CRP levels in the group Ⅲ-Ⅳ were significantly higher than those in the group Ⅰ-Ⅱ（P〈0.01）,while there was no significant difference with serum SA（P〉0.05）.Conclusions Acute-phase proteins prove to be related closely to cardiac function,but not to LVEF.

关 键 词：纤维蛋白原 唾液酸 C反应蛋白 心力衰竭 

分 类 号：R446.1[医药卫生—诊断学]