肾上腺髓质素抑制溶血磷脂酸的促平滑肌细胞增殖作用  

Adrenomedullin inhibits the lysophosphatidic acid-induced proliferation of vascular smooth muscle cells

作　　者：王晓红[1] 苏加林[1] 李夏[1] 安国顺[1] 安松柱 汤健[1] 唐朝枢[1] 王述恒[1] 刘乃奎[1] 

机构地区：[1]北京医科大学心血管基础研究所

出　　处：《中国病理生理杂志》1999年第4期343-345,共3页Chinese Journal of Pathophysiology

摘　　要：目的和方法：在培养的家兔血管平滑肌细胞上，观察了肾上腺髓质素（Ａｄｍ）对溶血磷脂酸（ＬＰＡ）诱导的ＤＮＡ合成和丝裂素活化蛋白激酶（ＭＡＰＫ）活性途径激活的影响。结果：ＬＰＡ使［３Ｈ］－ＴｄＲ掺入和ＭＡＰＫ活性增加，Ａｄｍ对基础水平的ＭＡＰＫ活性和［３Ｈ］－ＴｄＲ的掺入并无显著影响，但Ａｄｍ对ＬＰＡ刺激［３Ｈ］－ＴｄＲ掺入和ＭＡＰＫ活性具有抑制作用。结论：Ａｄｍ和ＬＰＡ相互作用参与血管平滑肌细胞增殖的调节。AIM and METHODS:The effect of adenomedullin(Adm) on lysophosphatidic acid(LPA)induced DNA synthesis and mitogen-activated protein kinase(MAPK) activity in cultured vascular smooth muscle cells(VSMCs) of rabbit was observed.RESULTS:LPA enhanced the cultured VSMCs -TdR incorporation and increased MAPK activity concurrently. Adm could not affect basal MAPK activity or -TdR incorportion,but inhibit LPA-induced -TdR incorporation and MAPK activity in a concentration-dependent manner.CONCLUSION:The action between Adm and LPA may play an important role in regulating the proliferation of VSMCs.

关 键 词：血管 平滑肌细胞 肾上腺髓质素 溶血磷脂酸 兔 

分 类 号：R543.02[医药卫生—心血管疾病]