冠心平对垂体后叶素致心肌缺血的实验研究  

An Experimental Study of GuanXinPing on Pituitrin-Induced Myocardial Ischemia

作　　者：王道成[1,2] 李七一[3] 朱萱萱[3] 严士海[3] 秦晓康[3] 马俊杰[3] 

机构地区：[1]南京中医药大学,江苏南京210029 [2]扬州市中医院,江苏扬州225002 [3]江苏省中医院,江苏南京210029

出　　处：《中华中医药学刊》2010年第7期1480-1482,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：康缘中医药科技创新基金资助(HZ0803KY)

摘　　要：目的:观察冠心平对大鼠实验性急性心肌缺血的保护作用。方法:采用大鼠尾静脉注射垂体后叶素(Pit)诱发急性心肌缺血模型,观察各组注射Pit后5min内心电图ST段、心率以及6h后血清乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)的变化,心肌病理损伤程度的影响。结果:冠心平对Pit所致急性缺血性心电图ST段和心率的变化都有明显改善作用,能显著降低L D H的含量,增加血清SOD的活性(P<0.05,P<0.01),心肌病理损伤程度明显减轻。结论:冠心平对Pit致大鼠急性心肌缺血具有明显的保护作用。Objective：To study the protection effect of GuanXinPing on pituitary induced acute myocardium ischemia.Methods：Pituitrin（Pit） was given to form model of acute myocardium ischemia.The changes of ECG（ST-segment）,heart rate after injection Pit via caudal vein in 5 minutes later and contents of LDH/SOD in serum was observed after 6 hours later.And to observe the experimental animal cardiac pathological damage extent.Results：GuanXinPing group can significantly improved the height of ST-segment and heart rate.The SOD activity was significantly enhanced and LDH contents was significantly reduced（P〈0.05,P〈0.01）.Cardiac pathological damage is reduced significantly.Conclusion：GuanXinPing have the functions of anti-acute myocardium ischemia.

关 键 词：心肌缺血 冠心平 垂体后叶素 

分 类 号：R285.5[医药卫生—中药学]