利培酮治疗对首发精神分裂症患者探究性眼动分析的影响  

Effect of Risperidone on Exploratory Eye Movement of Patients with First Episode Schizophrenia

作　　者：耿建萍 张幸福 

机构地区：[1]峰峰集团有限公司精神卫生中心,河北省邯郸市056202

出　　处：《职业与健康》2010年第16期1854-1855,共2页Occupation and Health

摘　　要：目的测定利培酮治疗首发精神分裂症患者前后探究性眼动分析(exploratory eyemovement EEM)的变化,以评定认知功能的改善。方法采用病例对照研究方法,设立利培酮组30例和正常对照组30例。EEM主要记录2个参数,即眼球运动注视点(NEF)和反应性探索分(RSS),运用EEM比较患者组利培酮治疗前、后与对照组认知功能的差异,比较患者组治疗前、后认知功能的改善情况,比较利培酮组治疗后EEM是否有差异。结果利培酮组治疗前与对照组NEF、RSS差异均有统计学意义(P<0.05)。利培酮组治疗后与治疗前比较存在统计学差异(P<0.05)。与对照组比较亦有统计学差异。结论首发精神分裂症患者存在认功能障碍,EEM测定可作为首发精神分裂症病人的辅助诊断指标。利培酮治疗后首发精神分裂症患者认知功能均得到改善,EEM测定可作为首发精神分裂症患者认知功能改善的评估指标之一。[Objective]To determine the variation of exploratory eye movement（EEM） of patients with first episode schizophrenia receiving Risperidone therapy,so as to evaluate the improvement of cognitive function.[Methods]A case-control study was employed to conduct analysis on Risperidone group（30 cases） and control group（30 cases）.Two parameters of EEM were recorded,including Number of Eye Fixation（NEF） and Responsive Search Score（RSS）.By using EEM,the differences of cognitive function between Risperidone group and control group before and after Risperidone therapy were compared,and the improvement of cognitive function in Risperidone group was studied,as well as the change of EEM in Risperidone group.[Results]The differences of NEF and RSS between Risperidone group and control group before Risperidone therapy were significant（P〈0.05）.The difference in Risperidone group before and after therapy was significant（P〈0.05）,comparing with control group,the differences were also significant.[Conclusion]Cognitive dysfunction exists in patients with first episode schizophrenia,EEM can be taken as assistant diagnostic index for first episode schizophrenia.After Risperidone therapy,the cognitive function of patients can be improved.EEM determination can be one of the evaluation indexes for cognitive function improvement in patients with first episode schizophrenia.

关 键 词：精神分裂症 认知功能 眼动分析 利培酮 

分 类 号：R181.3[医药卫生—流行病学]