回顾性分析ACEI／ARB联用激素对微小病变型肾病综合征的影响  

Review analysis on the effect of angiotensin-converting enzyme inhibitor and or angiotensin receptor antagonist(ACEI/ARB) combined with prednisone on minimal change nephropathy

作　　者：刘双信[1,2,3] 史伟[1,2] 李睿均[1,2,4,5] 梁馨苓[1,2] 劳海燕[1,2] 叶智明[1,2] 章斌[1,2] 何朝生[1,2] 夏运风[1,2] 徐丽霞[1,2] 

机构地区：[1]广东省人民医院肾内科 [2]广东省医学科学院,广州510080 [3]南方医科大学 [4]广东药学院 [5]广东省医药采购服务中心

出　　处：《中国临床药理学杂志》2010年第7期495-498,共4页The Chinese Journal of Clinical Pharmacology

基　　金：广东省自然科学基金资助项目(8151008004000022,06020902);广东省科技攻关基金资助项目(2007B031503004,2007B030701003,9305)

摘　　要：目的研究血管紧张素转换酶抑制剂/血管紧张素受体拮抗剂(ACEI/ARB)联合激素治疗微小病型肾病综合征(MCD)的疗效。方法回顾性分析1998年11月至2006年10月肾活检确诊为MCD的患者,分为激素单联用ACEI或ARB组、激素联用ACEI及ARB组,及单用激素组作为对照。结果符合入组94例,激素单联用ACEI或ARB组(36例),复发率52.78%;激素联用ACEI及ARB组(30例),复发率56.67%;单用激素组(28例),复发率46.43%,其复发率及尿蛋白转阴时间均无统计学差异(P>0.05)。结论激素联用ACEI及或ARB不能降低MCD患者的复发率及缩短尿蛋白转阴时间。Objective To study the effect of angiotensin - converting enzyme inhibitor and or angiotensin receptor antagonist （ACEI/ARB） combined with prednisone on minimal change nephropathy （MCD）. Methods Ninety -four patients with minimal change nephropathy were divided into prednisone combined with ACEI or ARB group, prednisone combined with ACEI and ARB group, and single -use prednisone group （control） during November 1998 - October 2006. Results Prednisone combined with ACEI or ARB group were 36 cases, relapse rate was 52.78%. Prednisone combined with ACEI and ARB group were 30 cases, relapse rate was 56.67%. Single -use prednisone group were 28 cases, relapse rate was 46.43%. The relapse rate and remission time of proteinuria was no significant difference between no combined group and prednisone combined with ACEI and or ARB group （ P 〉 0. 05 ）. Conclusion ACEI and or ARB combined with prednisone in patients with MCD did not reduce the relapse rate and increase the likelihood and duration of remission.

关 键 词：微小病变型肾病 激素单用或联用ACEI/ARB 复发率 

分 类 号：R692[医药卫生—泌尿科学] R977.1[医药卫生—外科学]