噪声对降钙素基因相关肽的效应的实验研究  

The effect of noise on calcitonin gene related peptide

作　　者：能强[1] 赵宗群[1] 叶康平[1] 

机构地区：[1]北京医科大学劳动卫生教研室

出　　处：《职业医学》1999年第1期1-2,共2页China Occupational Medicine

基　　金：国家自然科学基金

摘　　要：接触噪声１、４、８周（Ｗ）后，敏感型大鼠（Ａ类）下丘脑ＣＧＲＰ含量明显低于Ａ类对照组。暴露８Ｗ后，不敏感型大鼠（Ｂ类）接触组下丘脑ＣＧＲＰ含量也明显低于Ｂ类大鼠对照组。本研究还观察到噪声接触４、８Ｗ后，Ａ、Ｂ类反应大鼠接触组大脑皮层中ＣＧＲＰ含量均明显低于各自对照组。接触８Ｗ后，Ａ类反应大鼠接触组血浆中ＣＧＲＰ浓度明显低于Ａ类反应对照组。以下丘脑为主的ＣＧＲＰ含量降低早于血压升高（８Ｗ后升高）。The level of calcitonin gene related peptide (CGRP) in hypothalamus in type A rats decreased significantly in comparison with that of the control group after 1, 4,8 weeks of noise exposure; so did type B rats but after 8 weeks. The level of CGRP in cerebral cortex in both types decreased significantly in comparison with that of the corresponding control group respectively. In addition, the level of CGRP in plasma of type A rats decreased significantly after 8 weeks in comparison with that of the control one. Those CGRP changes were earlier than the blood pressure change particularly in hypothalamus. It suggested that CGRP might participate in the blood pressure regulation during noise exposure.

关 键 词：噪声 下丘脑 血压 CGRP 

分 类 号：TB53[理学—物理]