多孔羟基磷灰石微球的原位转化制备研究  

Porous hydroxyapatite microspheres formed by a situ conversion process

作　　者：赵颖[1] 徐为[1] 姚爱华[1] 黄文旵[1] 

机构地区：[1]同济大学材料科学与工程学院,上海200092

出　　处：《功能材料》2010年第7期1124-1126,共3页Journal of Functional Materials

基　　金：上海市科委"创新行动计划"基础研究重点资助项目(08JC1419200)

摘　　要：利用锂钙硼(LCB)玻璃在磷酸盐溶液中的原位转化反应制备多孔的羟基磷灰石(HAP)微球,通过XRD、SEM和FTIR对微球的物相组成、形貌等进行了表征。结果表明,微球具有良好的多孔结构,表现为非晶态特性,600℃热处理后,转变成HAP晶体,同时HAP部分分解转变为Ca3(PO4)2。此外,对多孔HAP微球的形成机理进行了分析。在磷酸盐溶液中,玻璃表面原位生成Ca-P-OH水化物,并在玻璃表面原来Ca2+的位置沉积下来,形成微球壳,而由Li+和B3+占据的位置,因其溶出形成孔隙。这样的结构将使之成为良好的药物载体。Porous hydroxyappatite （HAP） microspheres were prepared by a situ Li-Ca-B glass conversion process.The phase composition,morphology and pore structure on the shell wall were investigated using XRD,SEM and FTIR.The results showed that the resulting microspheres possessed good internal porous structure.After heat treated at 600℃ for 2h,HAP is transformed from amorphous to crystal structure.Meanwhile,HAP is partially decomposed to Ca3（PO4）2.Furthermore,the formation mechanism of the porous HAP microsphere was also suggested.On immersing in phosphate solution,Ca-P-OH hydrate was in situformed on the surface of the glass and precipitated in the position occupied by Ca2＋,while the pores were formed in the position occupied by Li＋ and B3＋.These porous HAP microspheres may be useful for drug delivery.

关 键 词：羟基磷灰石 多孔微球 硼酸盐玻璃 

分 类 号：TB321[一般工业技术—材料科学与工程]