氟罗沙星和洛美沙星抗菌活性的研究  

STUDIES ON ANTIBACTERIAL ACTIVITY OF DOMESTIC FLEROXACIN AND LOMEFLOXACIN

作　　者：赵敏[1,2] 姜素椿[1,2] 王睿 

机构地区：[1]解放军302医院 [2]解放军总医院临床药理研究室

出　　处：《中国新药杂志》1999年第1期24-26,共3页Chinese Journal of New Drugs

摘　　要：目的：评价氟罗沙星和洛美沙星的体内外抗菌活性。方法：采用琼脂平板稀释法测最小抑菌浓度，微量稀释法测血清杀菌活性。结果：氟罗沙星和氧氟沙星对大肠杆菌、肺炎克雷白杆菌、痢疾杆菌及金葡菌体外抗菌活性相似，其ＭＩＣ９０为０．２５～２ｍｇ／Ｌ，洛美沙星对上述菌的ＭＩＣ９０较氧氟沙星及氟罗沙星高２～４倍。氧氟沙星、氟罗沙星及洛美沙星对大肠杆菌、肺炎杆菌及痢疾杆菌的峰时血清杀菌活性≥１∶８的百分率分别为８０％～１００％，９０％～１００％和５０％～８０％。结论：与氧氟沙星相似，氟罗沙星对大肠杆菌、肺炎克雷白菌及痢疾杆菌具有较强的体外抗菌活性和体内杀灭作用，是治疗肠杆菌感染的有效药物。OBJECTIVE:The antibacterial activities in vitro and in vivo of domestic fleroxacin and lomefloxacin were evaluated.METHODS:Minimum inhibitory concentration (MIC)and serum bactericidal activity (SBA)were determined by agar disk dilution and microplate method respectively.RESULTS:The antibacterial activities in vitro of fleroxacin are similar to that of ofloxacin in against E.Coli,K pneumonia,Shigella spp with a MIC 90 of 0.25～2 mg/L,but the MIC 90 of lomefloxacin in against bacterial species mentioned above are 2 to 4 fold of that of ofloxacin and fleroxacin .The percentage of peak SBA≥1∶8 in against E.Coli,Kpneumonia, and Shigella spp for ofloxacin,fleroxacin and lomefloxacin are 80%～100%,90%～100% and 50%～80%respectively( P <0.01).CONCLUSION:The antibacterial activities in vivo and in vitro of fleroxacin in against E.Coli,K pneumonia,and Shigella spp are similar to that of ofloxacin and even stronger than that of lomefloxacin.

关 键 词：氟罗沙星 洛美沙星 最小抑菌浓度 血清杀菌活性 

分 类 号：R978.19[医药卫生—药品]