冠心病患者氧化-抗氧化平衡检测及其临床意义  

Prooxidant-antioxidant balance determination in coronary heart disease patients and its clinical significance

作　　者：刘阳[1] 张义[2] 李英杰[2] 

机构地区：[1]武警湖南总队医院检验科,湖南长沙410006 [2]山东大学附属齐鲁医院检验科,山东济南250012

出　　处：《武警医学院学报》2010年第9期717-719,722,共4页Acta Academiae Medicinae CPAPF

摘　　要：【目的】探讨冠心病患者氧化-抗氧化平衡状态及其临床意义。【方法】设计氧化-抗氧化平衡状态检测方法,检测55例冠心病患者和38例健康志愿者血清氧化-抗氧化平衡状态并分析其差异。同时考察冠心病患者氧化-还原状态值与血清铜蓝蛋白及超敏C反应蛋白水平的相关性。【结果】冠心病患者组与健康志愿者组的氧化-还原状态值分别为(112.4±28.8)%和(78.4±22.6)%,冠心病患者组高于健康志愿者组,差异有统计学意义(P<0.05),且其氧化性高低与冠脉梗塞程度有关。冠心病患者氧化-还原状态值与血清铜蓝蛋白水平呈负相关,与超敏C反应蛋白水平呈正相关。【结论】冠心病患者氧化-抗氧化平衡状态倾向氧化性变化,检测氧化-抗氧化平衡状态有助于冠心病的诊断和研究。[Objective] To determinate the level of the prooxidant-antioxidant balance in coronary heart disease and its clinical significance. [Methods] For 55 coronary heart disease patients and 38 health volunteers, the prooxidant-antioxidant balance are measured with a novel method. The correlation between prooxidant-antioxidant balance value and serum ceruloplasmin, high sensitivity C-reactive protein level is also studied. [ Results ] The prooxidant-antioxidant balance values of coronary heart disease patients group and healthy volunteers group are （112.4 ±28.8）% and （78.4± 22.6）% respectively. A significant increase of the prooxidant- antioxidant balance value is observed in patients in comparison to control group （P 〈 0.05）, and its oxidation level is related to the degree of coronary infarction. The prooxidant-antioxidant balance value is negatively correlated with the serum ceruloplasmin level while positively correlated with the high sensitive C-reactive protein level. [ Conclusions]The prooxidant-antioxidant balance value is obviously increased when coronary heart disease occurred. It may provide a novel diagnosis and research tool for coronary heart disease.

关 键 词：冠心病 氧化应激 氧化-抗氧化平衡 

分 类 号：R541.4[医药卫生—心血管疾病]