颈动脉粥样硬化相关危险因素分析  

Analysis of carotid atherosclerosis risk factors

作　　者：李卫[1] 阿力木江[2] 王志强[1] 寇继寅[1] 刘备战[3] 宋萱[3] 

机构地区：[1]武警新疆总队医院神经内科,新疆乌鲁木齐830091 [2]武警新疆总队医院心内科,新疆乌鲁木齐830091 [3]武警新疆总队医院检验科,新疆乌鲁木齐830091

出　　处：《武警医学院学报》2010年第8期607-610,共4页Acta Academiae Medicinae CPAPF

摘　　要：【目的】分析高分辨率超声检测的颈动脉粥样硬化的危险因素。【方法】应用高分辨率超声波技术检测了507例患者颈动脉,根据结果将患者分为颈动脉粥样硬化组(397例)和对照组(110例)。所有患者均测定血压、血脂、尿酸(UA)、C-反应蛋白、同型半胱氨酸(Hcy)、胆红素等水平,进行单因素和多因素分析。【结果】两组间吸烟、高血压病史、糖尿病病史、体重指数(BMI)、收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、UA、Hcy和胆红素差异有统计学意义(P<0.05)。进一步多元回归分析发现LDL-C、糖尿病病史、高血压病史、吸烟、Hcy和TG是颈动脉粥样硬化的危险因素,而HDL-C为保护因素。【结论】心血管疾病的传统危险因素与颈动脉粥样硬化密切相关,而新的危险因素可以成为评价动脉粥样硬化的可靠指标。【Objective】To analyse the risk factors for carotid atherosclerosis detected by high frequency ultrasonography.【Methods】 507 in hospital patients were divided into carotid atherosclerosis group and control by high frequency carotid ultrasonography results.The atherosclerosis risk factors（blood pressure,serum lipids,uric acid,C-active protein,bilirubin,etc）were compared between them.Further multivariate regression analysis was performed to select the risk factors for carotid atherosclerosis.【Results】 Besides traditional risk factors,difference of other new risk factors were found between two groups,such as smoking,hypertension,diabetes,body mass index（BMI）,systolic blood pressure,diastolic blood pressure,serum lipids（except total cholesterol）,uric acid,homocysteine,C-active protein,and bilirubin.Multivariate regression analysis showed that LDL-C,diabetes,hypertension,smoking,homocysteine,and TG were major risk factors for atherosclerosis,but HDL-C functions as a protective agent.【Conclusions】 Traditional cardiovascular risk factors were closely related to carotid atherosclerosis,and new risk factors may also serve as raliable markers for atherosclerotic change.

关 键 词：同型半胱氨酸 尿酸 胆红素 危险因素 颈动脉 动脉粥样硬化 

分 类 号：R543.1[医药卫生—心血管疾病]