谷胱甘肽片人体药代动力学及相对生物利用度  

Pharmacokinetics and Relative Bioavailability of Glutathione Tablets

作　　者：杨淑群[1,2] 周远大[1,2] 何海霞[1,2] 姚高琼[1,2] 朱治本[1,2] 

机构地区：[1]重庆医科大学附属二院眼科 [2]重庆医科大学附属一院临床药理室

出　　处：《中国药房》1999年第1期30-31,共2页China Pharmacy

摘　　要：目的：测定谷胱甘肽片的药动学及相对生物利用度。方法：１０名健康男性志愿者单剂量随机交叉口服６００ｍｇ谷胱甘肽片后，经荧光分光光度法测定血浆药物浓度。结果：口服国产或进口谷胱甘肽片后血药浓度达峰时间分别为１．３５±０．２７ｈ和１．３５±０．２０ｈ，峰浓度分别为２３．１７±７．６６ｕｍｏｌ／Ｌ和２３．７９±７．１５ｕｍｏｌ／Ｌ，药－时曲线下面积分别为７３．７２±２５．１７ｕｍｏｌ／（ｈ·Ｌ）和７４．４９±１６．４９ｕｍｏｌ／（ｈ·Ｌ）。结论：结果表明两种片剂具有生物等效性。OBJECTIVE:To determine the pharmacokinetics and relative bioavailabihty of glutathione tablets. METHODS:The drugconcentrations in plasma were assayed by fluorescence spectrophotometry method dfter administration of a single oral dose of 600mgdomestic or imported glutathione tablets to each of 10 healthy male volunteers in a randomized crossover study. RESULTS: The peaklevels(tp) in plasma averaged 23. 17 ±7. 66umol/L and 23. 79 ±7. 15umol/L at 1. 35 ±0. 27 and 1. 35 ±0. 20h,and the areas underthe drug concentration curves(AUC) were 73. 27 ± 25. 17umol/(h . L) and 74. 49 ± 16. 49umol/(h · L) for domestic or importedglutathione tablets,respectively. CONCLUSION:The results showed that two formulations were bioequivalent.

关 键 词：谷胱甘肽 生物利用度 药代动力学 

分 类 号：R977.6[医药卫生—药品] R969.1[医药卫生—药学]