妊娠相关血浆蛋白A、高敏C反应蛋白与冠状动脉再狭窄的关系  

Correlation of Pregnancy-Associated Plasma Protein-A(PAPP-A)and High Sensitivity C-reactive Protein(hs-CRP)with Restenosis after Percuteneous Coronary Intervention

作　　者：吴桂平[1] 李颖[1] 张彦红[1] 付鑫[1] 曲晓婷[1] 邹慕蔚[1] 周瀛[1] 杨滢[1] 

机构地区：[1]沈阳医学院沈洲医院心血管内科,沈阳110002

出　　处：《中国医药导刊》2010年第7期1099-1100,共2页Chinese Journal of Medicinal Guide

基　　金：辽宁省教育厅科研资助项目(20060888)

摘　　要：目的:探讨妊娠相关血浆蛋白A(PAPP-A)、商敏c反应蛋白(hs-CRP)与经皮冠状动脉介入治疗(PCI)术后在狭窄的关系。方法:选择89例接受PCI治疗并于PCI术后6个月复查冠状动脉造影的患者,经冠脉造影证实出现支架内再狭窄的患者18例(再狭窄缎),未出现再狭窄的患者71例(无再狭窄组),测定入选患者PCI术前和术后血浆PAPP-A,hs-CRP水平并分析其支架内再狭窄情况。结果:再狭窄组患者术后血浆PAPP-A,hs-CRP水平较无再狭窄组高(P<0.01),且术后PAPP-A,hs-CRP水平与PCI术后冠状动脉后期内径丢失指数呈正相关(P<0.01)。结论:PCI术后血浆PAPP-A,hs-CRP水平可以预测冠状动脉再狭窄的发生。Objective：To investigate the relationship between plasma pregnancy-associated plasma protein-A（PAPP-A）, high sensitivity C.reactive protein（hs-CRP）and restenosis after percutaneous coronary intervention（PCI）.Methods：89 performed PCI and followed by repeated angiography 6 months after PCI were selected.Their baseline and follow-up angiograms were compared by quantitative coronary angiography to assess incidence of restenosis.They were assigned in restenosis group （n=18） and no restenosis group （n=71） by angiography.Plasma PAPP-A and hs-CRP were measured before and after PCI.Results：The leved of plasma PAPP-A and hs-CRP in restenonis group were significantly higher than that in no restenosis group after PCI （P〈0.01）.The change of later loss index of coronary artery lumen diameter was positive correlated with plasma PAPP-A and hs-CRP after PCI.Cnnclusion：Plasma PAPP-A and hs-CRP level after PCI possibly can forecasts the occurrence of restenosis after PCI.

关 键 词：妊娠相关血浆蛋白-A 高敏C反应蛋白 经皮冠状动脉介入治疗 冠状动脉再狭窄 

分 类 号：R543[医药卫生—心血管疾病]