大黄注射液对犬血管搭桥术后纤溶系统的影响  

Effects of Rhubarb Injection on Fibrinolytic System of Dogs after Vascular Bypass Surgery

作　　者：蔡惠芬[1] 罗鹏[1] 王珂[2] 徐在品[1] 王定坤[1] 高俊波[1] 赵伟[1] 王清宇[1] 彭尧[1] 邓小燕[3] 

机构地区：[1]贵州大学动物科学学院动物医学系,贵阳550025 [2]大连医科大学附属第一医院,大连116011 [3]北京航天航空大学生物与医学工程学院,北京100083

出　　处：《畜牧兽医学报》2010年第7期897-901,共5页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金项目(10772054;10572029);国家自然科学基金重点项目(10632010)

摘　　要：为研究大黄注射液对犬血管搭桥术后纤溶系统的影响,将20只犬随机分为高(0.8 g.kg-1)、中(0.4g.kg-1)、低剂量组(0.08 g.kg-1)及对照组,同侧自体颈外静脉重建颈总动脉,头静脉滴注大黄注射液,ELISA定量分析测定术前及术后1、2、3、5、7、14、21 d纤溶系统各指标的变化。结果显示,用药后血小板α颗粒膜蛋白、D-二聚体、纤溶酶原激活剂的抑制物-1显著降低,组织纤溶酶原激活剂显著升高,且成剂量依赖关系;血清纤维蛋白(原)降解产物无显著变化。结果表明,大黄注射液能纠正搭桥术后血液高凝状态,恢复抗凝系统活性,预防血栓形成。To investigate the effects of Rhubarb injection on fibrinolytic system after vascular bypass surgery,twenty hybridization dogs were divided to four groups randomly,which were control,high dosage（0.8 g·kg^-1）,middle dosage（0.4 g·kg^-1） and low dosage group（0.08 g·kg^-1）.The common carotid artery was reconstructed with jugular vein from the same side.Administration of Rhubarb injection was intravenous transfusion through vena cephalica accessoria.Parameters of fibrinolytic system was detected by ELISA quantitative assay before operation,1,2,3,5,7,14,21 d postoperatively.Results were as follows：（1） Granule membrane protein 140,D-dimer,plasminogen activator inhibitor-1 was significantly reduced;（2） Tissue-type plasminogen activator was significantly increased;（3） Fibrinogen degradation products had no change.Results showed that Rhubarb injection could retrieve blood hypercoagulable state of fibrinolytic system,recovery activity of anticoagulation system and prevent thrombogenesis after vascular bypass surgery.

关 键 词：大黄注射液 纤溶系统 血管搭桥 犬 

分 类 号：R541.4[医药卫生—心血管疾病]