急性冠脉综合征患者外周血中基质金属蛋白酶-2和白介素-18的含量变化及意义  

Variation and significance of peripheral blood matrix metalloproteinase-2 and interleukin-18 in patients with acute coronary syndrome

作　　者：陈涛[1] 张绪洪[1] 朱兴雷[1] 

机构地区：[1]山东大学附属省立医院心内科,济南250021

出　　处：《山东大学学报（医学版）》2010年第7期115-118,共4页Journal of Shandong University:Health Sciences

基　　金：山东省医药卫生计划项目资助项目(2003HW102);鲁科基金资助项目(Y2002C47)

摘　　要：目的观察急性冠脉综合征(ACS)患者基质金属蛋白酶-2(MMP-2)、白介素-18(IL-18)和纤维蛋白原(Fib)的含量变化及意义。方法选择56例ACS患者,其中不稳定心绞痛(UA)32例作为UA组,急性心肌梗死(AMI)24例作为AMI组,稳定性心绞痛36例作为SAP组,健康成人40例作为对照组,采用ELISA法检测ACS患者发病后第1天、第3天和第10天血清中的MMP-2、IL-18浓度,Clauss法检测Fib的浓度,并与对照组进行比较。结果 UA组和AMI组患者血清中MMP-2和IL-18浓度均高于SAP组和对照组﹙P<0.05),Fib浓度无明显差异﹙P>0.05﹚。ACS组患者血清中MMP-2的含量于发病后第1天达到峰值,此后逐渐下降;IL-18在发病后第3天达到峰值。结论 MMP-2和IL-18在ACS的发病过程中起重要作用。Objective To investigate the concentration changes of matrix metalloproteinase-2（MMP-2）,interleukin-18（IL-18） and fibrinogen in patients with acute coronary syndrome（ACS） and their significance.Methods Levels of MMP-2 and IL-18 were measured by ELISA in 32 patients with unstable angina pectoris（UAP）,24 patients with acute myocardial infarction（AMI）,36 patients with SAP（stable angina pectoris） and 40 healthy subjects.The level of fibrinogen was measured with the Clauss method.Results Levels of MMP-2 and IL-18 were higher in the UA and AMI groups than in the SAP group and control group（P 0.05 ﹚,while there was no significant difference in the level of fibrinogen among the four groups ﹙ P 0.05 ﹚.In patients with ACS,the peak value of MMP-2 appeared on day 1,followed by a gradual decrease up to day 10,whereas IL-18 on day 3.Conclusion MMP-2 and IL-18 play an important role in the pathogenesis of ACS.

关 键 词：急性冠脉综合征 基质金属蛋白酶-2 白细胞介素-18 

分 类 号：R541.4[医药卫生—心血管疾病]