超声辅助微弧氧化钛合金表面制备含镧涂层的生物相容性评价  

Ultrasound-assisted micro-arc oxidation to prepare biocoatings containing lanthanum on the surface of titanium alloy:Biocompatibility evaluation

作　　者：刘继光[1] 包殿瑞[1] 毕庆伟 邬志锋[1] 李慕勤 

机构地区：[1]佳木斯大学附属第二医院口腔医院,黑龙江佳木斯市154002 [2]黑龙江省口腔病防治院,黑龙江哈尔滨市150001 [3]黑龙江省高校生物医学材料重点实验室,黑龙江省佳木斯市154007

出　　处：《中国组织工程研究与临床康复》2010年第29期5351-5354,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:稀土元素具有一定的生物效应,也有广谱抗菌、抗炎和抗病毒的能力,能提高涂层结合强度作用。目的:在种植体涂层中引入稀土镧,对引入稀土元素镧的钛基超声辅助微弧氧化涂层的生物相容性进行评价。方法:利用超声辅助微弧氧化在β型钛合金表面制备含镧生物涂层,并植入家兔股骨内。以钛合金基体和未加镧生物涂层作对照。采用光镜观察新骨形成,通过扫描电镜观察种植体与骨的结合情况和拔出种植体后其表面骨残留,并对骨接触率进行数据统计。结果与结论:实验组种植体周围新骨形成良好,未见到纤维形成和破骨细胞;扫描电镜观察及骨接触率以实验组最好,钛合金组最差。结果说明超声辅助微弧氧化制备的含镧生物涂层具有与新骨良好结合的能力,显示出较好的生物相容性。BACKGROUND：Rare earth elements have some biological effects,and broad-spectrum anti-bacterial,anti-inflammatory and anti-virus capabilities,they can increase the bonding strength.OBJECTIVE：To introduce rare earth lanthanum into the implant coating,and to evaluate the biocompatibility of ultrasound-assisted micro-arc oxidation preparing the lanthanum biocoating.METHODS：Using ultrasound-assisted micro-arc oxidation,the biocoating containing lanthanum was prepared on the surface of the near β-type titanium alloy,and implanted in rabbit femur.The titanium alloy matrix and the micro-arc oxidation biocoating without lanthanum served as the control group.Optical microscope was used to observe the formation of new bone;Scanning electron microscopy was applied to observe the combination interface of implant and bone,and the bone residue after pulling the implant;the bone contact rate was statistically analyzed.RESULTS AND CONCLUSION：In the experimental group,the new bone formed surrounding the implant without any fibers and osteoclasts;Scanning electron microscopy and bone contact rate are the best in the experimental group and the worst in the titanium alloy group.This shows that ultrasound-assisted micro-arc oxidation preparing the lanthanum biocoating can achieve high osseointegration and good biocompatibility.

关 键 词：种植体 镧离子 钛合金 超声波 微弧氧化 

分 类 号：R318[医药卫生—生物医学工程]