药物支架材料特征与置入后再内皮化及晚期血栓形成的评价  

Material characteristics,re-endothelialization and late stent thrombosis of drug eluting stent

作　　者：彭峰林 

机构地区：[1]广西师范大体育学院,广西壮族自治区桂林市541004

出　　处：《中国组织工程研究与临床康复》2010年第29期5447-5450,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:评价不同种类药物支架再内皮化和晚期血栓形成方面的差异及机制,探讨药物支架研发的方向。方法:以"血管内支架,内皮化,药物支架,晚期血栓"为中文关键词;以"intravascular stent,re-endothelialization,drug eluting stent,late stent thrombus"为英文关键词,采用计算机检索1993-01/2010-04相关文章。纳入与药物支架内皮化及晚期血栓相关的文章;排除重复研究或Meta分析类文章。以33篇文献为主重点讨论了不同种类药物支架的内皮化与晚期血栓形成差异及机制。结果:不同种类的药物支架再内皮化存在差异,抗血管平滑肌增殖类药物支架在临床上应用最为广泛,但由于其内皮化延迟可能导致晚期血栓的出现,影响其临床疗效和应用。其他种类药物支架的再狭窄率比抗血管平滑肌增殖药物支架高。解决药物支架内皮化不全是改善药物支架的一个中心。结论:理想的涂层药物既能有效抑制血管内膜增生、又能使血管内皮良好覆盖支架,以防止晚期血栓的出现。OBJECTIVE：To evaluate the difference and mechanisms underlying the re-endothelialization and late stent thrombosis in different types of drug eluting stents,to explore the research and development direction of new drug eluting stent.METHODS：A computer-based online search was performed for articles published from January 1993 to April 2010 with the key words of＂intravascular stent,re-endothelialization,drug eluting stent,late stent thrombus＂in English and Chinese.Studies regarding re-endothelialization and late stent thrombus of drug eluting stent were included.The repetitiveness or Meta papers were excluded.Totally 33 articles mainly focus the difference and mechanisms underlying the re-endothelialization and late stent thrombosis in different types of drug eluting stents.RESULTS：Re-endothelialization is different in several kinds of drug eluting stents.Vascular smooth muscle cell antiproliferative drug eluting stents are widely used in the clinical practice,but the delayed endothelialization may lead to late thrombosis,thereby affecting the clinical efficacy and application.Other kinds of drugs eluting stent exhibited higher restenosis rate than vascular smooth muscle cell antiproliferative drug eluting stents.To solve incomplete stent endothelialization of drug eluting stent is a key issue of improving drug stent.CONCLUSION：Ideal coating drugs can effectively inhibit vascular intimal hyperplasia,but also induce vascular endothelium to well cover stent,thus preventing the emergence of late thrombosis.

关 键 词：内皮化 晚期血栓 血管再狭窄 药物支架 血管内支架 

分 类 号：R318[医药卫生—生物医学工程]