小干扰RNA抗病毒研究进展  

Recent Progress of Small Interfering RNA in Antiviral Researh

作　　者：魏强[1] 曹博[1] 郭韬[1] 李广林[1] 

机构地区：[1]陕西师范大学生命科学学院,陕西西安710062

出　　处：《生物技术通讯》2010年第4期571-574,共4页Letters in Biotechnology

基　　金：国家自然科学基金(60970005/F020102);陕西师范大学科研项目(200802010)

摘　　要：小干扰RNA(siRNA)介导的对同源基因转录后水平的抑制或由此引发的细胞质内同源mRNA降解的转录后基因沉默现象,在抗病毒研究中具有重要意义。由病毒感染引起的各种疾病严重危害着人类的健康,而siRNA在抗病毒感染的研究领域中显示出高度特异性,故受到人们的普遍关注。近年来,siRNA抗病毒方面的研究成为国内外的热点,为临床病毒感染性疾病的防治提供了新的途径。我们就siRNA的机制和特点、siRNA的制备及其抗病毒研究进展做简要综述。The inhibition mediated by small interfering RNA（siRNA） in post-transcriptional level of homologous genes or the post-transcriptional gene silencing of cellular homologous mRNA caused by the inhibition has important meanings in antiviral researches. So far a series of viral diseases have been a global health problem, while siRNA which is widely thought highly of shows a strong and specific effect in the areas of antiviral researches. Recent work on antiviral siRNA has become a focus highlight and provided a new way in clinical prevention and therapeutics of viral diseases. This review focused the recent researches on the mechanism, characteristic and preparation of siRNA and its related antiviral progress.

关 键 词：小干扰RNA 病毒感染 基因沉默 抗病毒 

分 类 号：Q74[生物学—分子生物学]