单核铜配合物Cu(C_(16)H_(13)N_2OS_2)_2的合成、晶体结构和生物活性(英文)  

Synthesis,Crystal Structure and Biological Activity of a New Mononuclear Copper Complex Cu(C_(16)H_(13)N_2OS_2)_2

作　　者：仇晓阳[1,2] 刘瑛[1] 程艳[1] 郑昕[1] 朱海亮[2] 

机构地区：[1]商丘师范学院化学系,商丘476000 [2]医药生物技术国家重点实验室,南京210093

出　　处：《无机化学学报》2010年第8期1485-1489,共5页Chinese Journal of Inorganic Chemistry

基　　金：河南省教育厅项目(No.2009A150020);安徽省教育厅项目(No.KJ2008B1780)资助

摘　　要：A planar copper complex Cu(L)2,HL=(E)-benzyl-2-(4-formylbenzylidene)-Hydrazinecarbodithioate,has been prepared via the template effect of copper ion. Crystal structure of the complex was determined by X-ray singlecrystal diffraction analysis. The crystal data for this complex:Orthorhombic,space group Pbcn,a=2.250 0(14) nm,b=1.660 0(11) nm,c=0.830 4(5) nm,V=3.102(3) nm3,Z=4,μ=1.011 mm-1,Dc=1.478 g·cm-3,F(000)=1 420,R1= 0.050 1,wR2=0.087 2 (observed reflections with I>2σ(I)) and R1=0.129 1,wR2=0.100 9 (all reflections) GOF= 1.011. In the compound,Cu(Ⅱ) atom is four-coordinated with two N atoms and two S atoms from two bidentate ligands and located in the inversion center. The preliminary bioassay indicates that the complex exhibits distinct antitumor activity.A planar copper complex Cu（L）2,HL=（E）-benzyl-2-（4-formylbenzylidene）-Hydrazinecarbodithioate,has been prepared via the template effect of copper ion. Crystal structure of the complex was determined by X-ray singlecrystal diffraction analysis. The crystal data for this complex：Orthorhombic,space group Pbcn,a=2.250 0（14） nm,b=1.660 0（11） nm,c=0.830 4（5） nm,V=3.102（3） nm3,Z=4,μ=1.011 mm-1,Dc=1.478 g·cm-3,F（000）=1 420,R1= 0.050 1,wR2=0.087 2 （observed reflections with I2σ（I）） and R1=0.129 1,wR2=0.100 9 （all reflections） GOF= 1.011. In the compound,Cu（Ⅱ） atom is four-coordinated with two N atoms and two S atoms from two bidentate ligands and located in the inversion center. The preliminary bioassay indicates that the complex exhibits distinct antitumor activity. CCDC：763155.

关 键 词：铜配合物 平面结构 晶体结构 生物活性 

分 类 号：O614.121[理学—无机化学]