异丙酚对高血压脑出血手术患者血清炎性细胞因子的影响  

Effects of Propofol on Serum Inflammatory Cytokines in Operative Patients with Hypertensive Brain Bleeding

作　　者：程永冲[1] 王显悦[2] 吴畏[1] 

机构地区：[1]解放军第三医院麻醉科,陕西宝鸡721004 [2]广州军区总医院麻醉科

出　　处：《华西医学》2010年第5期860-861,共2页West China Medical Journal

摘　　要：目的明确异丙酚对于高血压脑出血患者血清炎性细胞因子的影响。方法将2008年3月2009年3月收治的高血压脑出血患者47例分为两组,异丙酚组采用异丙酚、芬太尼、维库溴铵以及异氟醚诱导和维持麻醉;对照组采用依托咪酯、芬太尼、维库溴铵以及异氟醚诱导和维持麻醉。比较两组患者手术中不同时段血清白细胞介素(IL-6)、肿瘤坏死因子(TNF)、血栓素、内皮素、前列腺素E和降钙素水平。结果患者麻醉过程中生命体征平稳,无麻醉相关死亡。术前异丙酚组患者血清IL-6、TNF、血栓素、内皮素、前列腺素E和降钙素水平与对照组比较均无差异(P>0.05),而麻醉诱导后差异有统计学意义(P<0.05),而且差异随时间延长增大。结论采用异丙酚麻醉能降低术中血清炎性细胞因子水平。Objective To identify the effects of propofol on serum inflammatory cytokines in operative patients with hypertensive brain bleeding. Methods A total of 47 patients with hypertensive brain bleeding were randomly divided into two groups according to anesthetic methods from March 2008 to March 2009. In propofol group, the patients were anesthetized with propofol, fentanyl, vocuronium bromide and isoflurane; and in control group the patients were anesthetized with etomidate, fentanyl, vocuronium bromide and isoflurane. The records from two groups were compared on interleukin （IL-6）, tumor necrosis factor （TNF）, thromboxane （TX）, endothelin （ET）, prostaglandin E （PGE） and calcitonin （CT）. Results There were no anesthesia-related death in two groups and vital sign of each patient was steady. Serum IL-6, TNF, TX, ET, PGE and CT in propofol group had no significant difference from those in control group before operation （P0. 05）, while after anesthesia there were statistically significant differences between the two groups （P0.05）. The difference was enhanced steadily with operation going. Conclusion Propofol anesthesia can reduce the level of inflammatory cytokines during operation.

关 键 词：异丙酚 高血压脑出血 炎性细胞因子 

分 类 号：R614[医药卫生—麻醉学]