视网膜血管直径与2型糖尿病视网膜病变的关系  

Relationship between Retinal Vessel Caliber and Diabetic Retinopathy of Type 2 Diabetes Mellitus

作　　者：郭倩茹[1] 徐应军[2] 

机构地区：[1]唐山市工人医院分院眼科,河北唐山063003 [2]华北煤炭医学院科研处

出　　处：《华西医学》2010年第5期895-897,共3页West China Medical Journal

摘　　要：目的探讨视网膜微血管直径与2型糖尿病(DM2)并发症糖尿病视网膜病变(DR)的关系。方法选取2009年1月11月住院确诊DM2患者200例,根据眼底彩色照相结果将患者分为DR组和NDR组,测量视网膜血管直径、测定生化指标及血压,用非条件Logistic回归分析糖尿病视网膜病变发生的危险因素。结果 V1扩张10μm时,DM2患者并发DR危险性增加(OR1.75,95%CI1.14～3.04,P<0.05);空腹血糖水平增加1mmol/L,DM2患者并发DR的危险性增加(OR1.87,95%CI1.43～2.81,P<0.05);糖化血红蛋白增加1个单位,DM2患者并发DR的危险性增加(OR1.08,95%CI1.02～1.13,P<0.05);DM病程增加1年,DM2患者并发DR的危险性增加(OR1.41,95%CI1.18～1.70,P<0.05)。结论在DM2患者中,视网膜静脉直径大小、空腹血糖水平、糖化血红蛋白水平、糖尿病病程是DR发生的危险因素。Objective To explore the relationship between retinal vessel caliber and diabetic retinopathy （DR） in patients with type 2 diabetes mellitus （DM2）. Methods From January to November 2009, 200 diabetic patients were examined with fundus color photo and divided into DR and NDR groups. The diameter of vessel was measured using computer-assisted imaging program. Blood collection was examined and blood pressure was measured. Logistic analysis was used to identify the risk factors of DR. Results In DM2, the risk of developing DR was increased when the retinal venous diameters （V1） dilated by 10 μm （OR 1.75, 95% CI 1.14-3.04, P0.05）. The risk of developing DR was increased when fasting blood glucose added by 1 mmol/L （OR 1.87, 95% CI 1.43-2.81, P0.05）. The risk of developing DR was increased when glycosylated hemoglobin added by one unit （OR 1.08, 95% CI 1.02-1.13, P0.05）. The risk of developing DR was increased when the duration of DM added by one year （OR 1.41, 95% CI 1.18-1.70, P0.05）. Conclusion In DM2, the retinal venous diameters’ dilation, fasting blood glucose, glycosylated hemoglobin, and the duration of DM are the risk factors of developing DR.

关 键 词：2型糖尿病 视网膜血管直径 视网膜病变 

分 类 号：R587.1[医药卫生—内分泌] R774[医药卫生—内科学]