326例眼表面肿块组织病理学分析  

Histopathological Analysis of 326 Cases of Ocular Surface Tumors

作　　者：蒋永强[1] 曾发平[1] 吴晓梅[1] 何为民[1] 

机构地区：[1]四川大学华西医院眼科,成都610041

出　　处：《华西医学》2010年第6期1080-1083,共4页West China Medical Journal

摘　　要：目的分析眼表面肿块的发病情况及组织病理学特点。方法对2004年1月2008年12月收治并经病理学证实的326例眼表面肿块患者的年龄、性别、眼别、肿块发生部位、肿块性质及病理类型进行回顾性分析。结果 326例眼表面肿块中,良性肿块264例(81.0%),恶性肿块62例(19.0%)。良性肿块中,前5位分别为色素痣67例(25.4)%,迷芽瘤63例(23.9)%,乳头状瘤39例(占14.8)%,结膜囊肿25例(9.5)%,炎性肉芽肿20例(7.6)%。恶性肿块中,前4位分别为鳞状细胞癌25例(40.3)%,淋巴瘤13例(21.0)%,恶性黑色素瘤12例(19.4)%,原位癌10例(16.1)%。结论眼球表面的肿块有共同的组织细胞起源,肿块的亚型表现出不同的组织结构、良恶性和好发部位;而同部位的良性、交界性和恶性病变的衍变发展,从某种程度上体现了一个疾病的不同发展阶段,三者间的鉴别和明确的病理诊断能为临床选择手术时机及手术方式提供依据。Objective To analyze the prevalence rate and histopathological characteristics of ocular surface tumors. Methods A total of 326 cases of ocular surface tumors from January 2004 to December 2008 were retrospectively reviewed and analyzed,according to the age,sex,locations of ocular surface tumors and their pathological types. Results In the 326 cases of ocular surface tumors,246 cases （81%） were pathologically benign ones,and 47 cases （19%） were malignant. In the malignant tumors,the top four as follows：squamous cell carcinoma were 25 cases （40.3%）; lymphoma were 13 cases （21%）; malignant melanoma were 12 cases （19.4%）; situ carcinoma were 10 cases,16%. While in the benign ones,the top five as follows：the nevus had 67 cases （25.4%）; fan bud tumors had 63 cases （23.9%）; the papilloma had 39 cases （14.8%）; conjunctival cyst had 25 cases （9.47%）; and the inflammatory granuloma had 20 cases （7.58%）. Conclusion Although the ocular surface tumors may have a common histological origin,the subtype could show different organizational structures,benign or malignant,and predilection sites. The benign lesions,borderline lesions and malignant lesions origined from the same part could evolute and develop each other. To some extent,it might reflecte the different development stages of one disease,but the identification and definite pathological diagnosis among them could provide a reliable basis for clinical ophthalmologists to determine the operation timly and choose appropriate surgical method.

关 键 词：角结膜肿块 组织病理学 分析 

分 类 号：R446.8[医药卫生—诊断学]