秦皮甲素平衡溶解度及表观油/水分配系数的研究  

Study on Equilibrium Solubility of Aesculin and Its Apparent Oil/Water Partition Coefficient

作　　者：姜宇[1] 何群[1] 

机构地区：[1]湖南中医药大学药学院,长沙市410007

出　　处：《中国药房》2010年第29期2725-2727,共3页China Pharmacy

摘　　要：目的:研究秦皮甲素的平衡溶解度及表观油/水分配系数,为其吸收机制研究奠定基础。方法:将秦皮甲素分别溶解于pH 1.2～8.0的不同介质中,以饱和法测定其平衡溶解度,摇瓶法测定其表观油/水分配系数。结果:秦皮甲素的平衡溶解度在pH1.2～6.8之间略有波动,pH 7.4时开始急剧增大,并在pH 8.0达到峰值(10.58 g·L-1);其表观油/水分配系数在pH 1.2～6.0之间变化缓慢,pH 6.0时开始明显下降,并在pH 8.0达到最低值(0.03)。结论:秦皮甲素的平衡溶解度及表观油/水分配系数与介质的pH值有关,其口服后无降低血尿酸作用的原因可能与胃肠道吸收较差有关。OBJECTIVE： To study the equilibrium solubility of aesculin and its apparent oil/water partition coefficient, and to provide basis for absorption mechanism study. METHODS： Equilibrium solubility of aesculin at the pH of 1.2-8.0 was determined by saturation method. The apparent oil/water partition coefficients of aesculin were determined by shaking flask method. RESULTS： The equilibrium solubility of aesculin at the pH of 1.2-6.8 was fluctuated slightly; it increased rapidly at the pH of 7.4; the maximum equilibrium solubility of aesculin was obtained at the pH of 8.0 （10.58 g· L^-1）. The oil/water partition coefficient of aesculin changed slowly at the pH of 1.2-6.0; it decreased significantly at the pH of 6.0; the minimum oil/water partition coefficient was obtained at the pH of 8.0 （0.03）. CONCLUSIONS： The equilibrium solubility of aesculin and its apparent oil/water partition coefficient are associated with the pH of medium. The reason that aesculin has no effect on uric acid after oral administration is relevant to poor gastrointestinal tract absorption ability.

关 键 词：秦皮甲素 平衡溶解度 表观油/水分配系数 高效液相色谱法 

分 类 号：R927.2[医药卫生—药学] R286.0