铬酸钾指示剂法测定度米芬原料药含量  

Content Determination of Domiphen by Potassium Chromate Indicator Method

作　　者：江相兰[1] 杨楠楠[1] 杨冬芝[1] 林奇泗[1] 

机构地区：[1]徐州医学院药学院,徐州市221004

出　　处：《中国药房》2010年第29期2770-2771,共2页China Pharmacy

摘　　要：目的:建立铬酸钾指示剂法测定度米芬原料药含量。方法:根据度米芬中溴阴离子能与AgNO3生成溴化银沉淀的原理,采用铬酸钾指示剂法测定度米芬原料药含量,并与2005年版《中国药典》采用的四苯硼钠法结果进行比较。结果:铬酸钾指示剂法RSD=0.18%,平均回收率为100.2%;2种测定方法结果经t检验表明无显著性差异。结论:铬酸钾指示剂法简便、快速、准确,也可用于度米芬原料药的含量测定。OBJECTIVE： To establish a method for the content determination of domiphen by potassium chromate indicator method.METHODS： The contents of domiphen were determined based on the theory that bromide ion in domiphon could react with AgNO3 to produce silver bromide precipitation.The method was compared with the sodium tetraphenylborate method issued in China Pharmacopeica（2005 edition）.RESULTS： The RSD of contents was 0.18%,and the average recovery was 100.2% in the potassium chromate indicator method.There was no significant difference between the results of two determination methods by t-test.CONCLUSION： The potassium chromate indicator method is simple,fast and accurate,which can be used for the content determination of domiphen.

关 键 词：度米芬 含量测定 铬酸钾指示剂法 四苯硼钠法 

分 类 号：R927.2[医药卫生—药学] R979.7