Simply air:Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air  

作　　者：Lu Yin Xian Jia Xing Shu Li Albert S.C. Chan 

机构地区：[1]School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China [2]School of Pharmaceutical Sciences,Sun Yat-Sen University,Guangzhou 510006,China

出　　处：《Chinese Chemical Letters》2010年第7期774-777,共4页中国化学快报（英文版）

基　　金：supported by National Natural Science Foundation of China(No.20472116) and 2009 intranational visiting doctoral student project of Ministry of Education.

摘　　要：Vanadium-catalyzed oxidative kinetic resolution（OKR） of methyl o-chloromandelate 2a,key intermediate of the well-known oral antiplatelet agent（S）-clopidogrel,was achieved by ambient air for the first time.The air oxidation system,which was composed of vanadium and tridentate Schiff base ligands derived from amino alcohols and salicylaldehyde derivatives,afforded an efficient and economic approach to the target intermediate with high enantioselectivities（99%ee）.Vanadium-catalyzed oxidative kinetic resolution（OKR） of methyl o-chloromandelate 2a,key intermediate of the well-known oral antiplatelet agent（S）-clopidogrel,was achieved by ambient air for the first time.The air oxidation system,which was composed of vanadium and tridentate Schiff base ligands derived from amino alcohols and salicylaldehyde derivatives,afforded an efficient and economic approach to the target intermediate with high enantioselectivities（99%ee）.

关 键 词：Ambient air Vanadium-catalyzed OKR Methyl o-chloromandelate Schiff base ligands 

分 类 号：O643.36[理学—物理化学] V211[理学—化学]