The design and synthesis of a novel organophosphorus compound containing the structure of both β-amino acid and β-aminophosphonate  

作　　者：Han Bing Teng 

机构地区：[1]College of Chemical Engineering,Wuhan University of Technology,Wuhan 430070,China

出　　处：《Chinese Chemical Letters》2010年第7期810-812,共3页中国化学快报（英文版）

摘　　要：A novel organophosphorus compound containing the structure of bothβ-amino acid andβ-aminophosphonate is designed and synthesized.Arbuzov reaction with P（OEt）_3,the N-Boc protected iodide 3 cannot provide the desired product but 2-oxazolidinone 4 because of the neighboring-group participation of the Boc moiety.To avoid the intramolecular participation of the carbamates,the Ts protecting group is employed and the Ts-protected iodide 5 affords the target product successfully.A novel organophosphorus compound containing the structure of bothβ-amino acid andβ-aminophosphonate is designed and synthesized.Arbuzov reaction with P（OEt）_3,the N-Boc protected iodide 3 cannot provide the desired product but 2-oxazolidinone 4 because of the neighboring-group participation of the Boc moiety.To avoid the intramolecular participation of the carbamates,the Ts protecting group is employed and the Ts-protected iodide 5 affords the target product successfully.

关 键 词：β-Amino acid β-Aminophosphonate Neighboring-group participation Arbuzov reaction Amino-protecting group 

分 类 号：O627.51[理学—有机化学] Q517[理学—化学]