A new derivative of triterpene with anti-melanoma B16 activity from Conyza canadensis  

作　　者：Ming Ming Yan Ting You Li Da Qing Zhao Shuai Shao Sheng Nan Bi 

机构地区：[1]Changchun University of Chinese Medicine,Changchun 130117,China [2]School of Pharmacy,Nanjing Medical University,Nanjing 210029,China

出　　处：《Chinese Chemical Letters》2010年第7期834-837,共4页中国化学快报（英文版）

摘　　要：A new derivative of triterpene named Erigeronol 1 was isolated from the EtOH extract of the aerial part of Conyza canadensis together with 15 known compounds for the first time from this plant.The structure of Erigeronol 1 was elucidated as 3-O-（hydroxyacetyl） -23,28-dihydroxy-β-amyrin by hydrolysis and spectroscopic analysis.Erigeronol 1 showed potent cytotoxic activity with IC_（50） value of 7.77±0.47μg/mL against melanoma B16 determined by the 3-（4,5-dimethylthiazo-2-yl）-2,5-diphenyltetrazolium bromide（MTT） method.A new derivative of triterpene named Erigeronol 1 was isolated from the EtOH extract of the aerial part of Conyza canadensis together with 15 known compounds for the first time from this plant.The structure of Erigeronol 1 was elucidated as 3-O-（hydroxyacetyl） -23,28-dihydroxy-β-amyrin by hydrolysis and spectroscopic analysis.Erigeronol 1 showed potent cytotoxic activity with IC_（50） value of 7.77±0.47μg/mL against melanoma B16 determined by the 3-（4,5-dimethylthiazo-2-yl）-2,5-diphenyltetrazolium bromide（MTT） method.

关 键 词：Conyza canadensis Derivative of triterpene Anti-melanoma B16 

分 类 号：O636.1[理学—高分子化学] Q78[理学—化学]