帕瑞昔布对骨科术后镇痛的疗效观察  

Efficacy of parecoxib in treatment of postoperative pain of orthopaedic patients

作　　者：罗华云[1] 陈崇伟[1] 吕智[1] 

机构地区：[1]山西医科大学第二医院骨科,太原030001

出　　处：《国际骨科学杂志》2010年第4期251-253,共3页International Journal of Orthopaedics

摘　　要：目的观察帕瑞昔布在骨科术后镇痛治疗中的疗效及安全性。方法选择2009年1～12月间骨科四肢手术后24 h内急性疼痛患者60例,随机分为肌注帕瑞昔布(40mg)组和肌注哌替啶(50mg)组,对比分析两组的急性疼痛缓解程度、疼痛缓解时间和不良反应发生率。选择2009年1～12月间骨科全麻术后患者60例,随机分为肌注帕瑞昔布(40 mg,bid)组和自控静脉镇痛泵组,观察两组术后24 h内镇痛效果及不良反应发生率。采用疼痛视觉模拟评分法评价疼痛程度。结果在术后急性疼痛镇痛中,肌注帕瑞昔布40mg的效果与肌注哌替啶50mg相当,但帕瑞昔布比哌替啶起效快,且疼痛缓解时间长,不良反应发生率低。在术后24 h内镇痛中,肌注帕瑞昔布(40mg,bid)的效果与使用静脉镇痛泵相似,但不良反应发生率低。结论帕瑞昔布具有高效和安全的镇痛特性,适合于骨科术后镇痛。Objective To assess the effectiveness and safety of cyclo-oxygenase-2（COX-2） inhibitor parecoxib as an analgesic in orthopaedic postoperative patients.Methods From Jan.to Dec.2009,sixty limb operative patients with acute postoperative pain in our hospital were selected and divided randomly into two groups.parecoxib（40 mg） was administered as the postoperative analgesia in experiment group and the pethidine（50 mg） in control group,the degree and time of pain alleviatation and the incidence of adverse effects were statistically compared in two groups.Moreover,sixty general anesthesia patients were selected and divided randomly into two groups,parecoxib（40 mg,bid） was administered as the postoperative analgesia in experiment group and patient controlled intravenous analgesia（PCIA） in control group,the analgesia effect and the incidence of adverse effects were statistically compared within first 24 hours after operation.Results For acute postoperative pain,the effects of parecoxib（40 mg） was similar to pethidine（50 mg）,with less adverse effects,more fast onset of action and more long alleviatation of pain.The effects of parecoxib（40 mg.bid） was similar to the PCIA.with less adverse effects in first 24 hours after operation.Conclusion Parecoxib is highly-efficient and safe for postoperative analgesia of orthopaedic patients.

关 键 词：帕瑞昔布 环氧化酶-2抑制剂 骨科术后疼痛 镇痛 

分 类 号：R614[医药卫生—麻醉学]