高氧液对特重烧伤休克期患者肾功能的保护作用  

The protection value of hyperoxic fluid to renal ruction in extra heavy burn shock stage patients

作　　者：冉丽[1] 肖虎[1] 禚莹莹[1] 王德昌[1] 栾保华[1] 霍然[1] 冯永强[1] 李强[1] 

机构地区：[1]山东大学附属省立医院烧伤整形科,山东济南250021

出　　处：《医学检验与临床》2010年第3期19-20,30,共3页Medical Laboratory Science and Clinics

基　　金：本课题受山东省自然科学基金（2006ZRB14001）,山东省卫生厅青年基金（200565）资助

摘　　要：目的探讨高氧液对特重烧伤休克期肾功能的保护作用。方法30例大面积烧伤患者随机分成两组，A高氧液组（15人）和B对照组（15人），分别输入高氧液和平衡盐水液，观察两组休克期第1、2个24h的总尿量及平均尿量，检测其伤后24、48h的尿素氮（BUN）、肌酐（Scr）。采用放射免疫分析法分别测定伤后24、48h血浆TNF—α和IL-6含量。结果与对照组比较。治疗组第1、2个24h尿量均明显增加；（P均〈0．01）。烧伤休克期A组各时相点血浆TNF—α、IL-6水平显著低于B组。（P〈0．01）。结论大面积烧伤病人早期复苏中静脉应用高氧液可明显减轻全身性炎症反应，对严重烧伤休克期患者的肾功能有保护作用。Objective To explore the value of hyperoxic fluid treatment in relieve postburn renal injury. Methods Thirty burn patients of big dimension were employed in two group, Apart of sampling venous blood two millimeter put into prevent coagulation of test - tube at 1 postburn day（PBD1）, PBD2,. Measurement level of TNF-α and IL-6 in plasma. Results Level of TNF- α and IL-6 in plasma of hyperoxic group were much lower than those of control group（ P 〈 0.01 ）. Conclusion With hyperoxic fluid treatment could prominent relieve systemic inflammatory response and protect renal function during early burn patient of big dimension revival.

关 键 词：高氧液 烧伤 休克 肾功能 TNF—α IL-6 

分 类 号：R473.6[医药卫生—护理学]