乙型肝炎患者HBVDNA含量与其肝功能改变及肝纤维化程度之间的关系研究  

Reserch on the correlation between the contents of serum HBVDNA and the change of liver function and liver fibrosis in hepatitis B patients

作　　者：程跃建 柏连华 张锦根 

机构地区：[1]江苏省盐城市第一人民医院,江苏盐城224001

出　　处：《医学检验与临床》2010年第3期26-27,共2页Medical Laboratory Science and Clinics

摘　　要：目的探讨乙型肝炎患者血清HBVDNA含量与其肝功能改变及肝纤维化程度之间的关系。方法检测512例未经治疗的乙肝患者血清HBVDNA、肝功能及四项肝纤维化指标。结果乙肝患者血清HBVDNA含量与其病情的严重程度不一致。临床各型乙肝中HBVDNA含量阳性组与阴性组之间ALT值均差别无显著性（P〉0．05）；临床各型乙肝中，肝纤维化指标HA、LN、PCⅢ和Ⅳ型胶原依次升高，然而其HBVDNA水平各组间却均无显著性差别（P〉0．05）。结论乙肝患者血清HBVDNA含量与其肝功能改变及肝纤维化进程无关，血清HBVDNA含量不能反映其病情的临床严重程度。Objective To evaluate the serum HBVDNA level in hepatitis B and its relation with liver function and liver fibrosis. Methods 512 untreated patients with hepatitis B were selected their serum HBVDNA level and liver function and the four liver fibroid indexes were detected. Results Serum HBVDNA level disaccord with state of their illness; serum ALT in those HBVDNA（ ＋ ）and HVCDNA（ - ）have no difference （P 〉 0. 05 ）. Among the hepatitis B, the four indexes- Hyaluronic acid （HA）, Laminin（LN）, ProcoUagen type Ⅲ（PCKI）and collagen type Ⅳ rise successively ; but serum HBVDNA level has no difference in every phase （ P 〉 0. 05）. Conclusions Serum HBVDNA level cannot reflect the state of hepatitis illness, and no correlation with the change of liver function and the progress of liver fibrosis.

关 键 词：乙型肝炎 HBVDNA 肝功能 肝纤维化 

分 类 号：R512.62[医药卫生—内科学]