梯度降压缺氧预激对小鼠心肌缺氧耐受性影响及其机制初探  

Effects of Repetitive Hypoxia Preconditioning on Myocardial Tolerance to Hyposia of Mice

作　　者：程超[1] 吴伟康[1] 韦广明 

机构地区：[1]中山医科大学,广州510089

出　　处：《深圳中西医结合杂志》1999年第1期22-24,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：卫生部科研课题!94-2-055

摘　　要：目的：探讨反复缺氧预激对小鼠缺氧耐受性的影响及其可能机制。方法：用正常小鼠及经五次梯度降压缺氧预激小鼠分别制备血浆及心肌匀浆。将来自正常小鼠及预激小鼠的血浆分别注入两组正常小鼠腹腔（Non－PP组和PP组），将来自正常小鼠及预激小鼠的心肌匀浆分别注入另两组正常小鼠腹腔（Non－PH组和PH组）。各小鼠分别于注射后30min置于28．7KPa低压缺氧环境下测心电活动时间（CEAT）。结果：PH组CEAT比Non－PH组延长1．80倍（P＜0．01），PP级CEAT比Non一PP组延长1．29倍（P＜0.01）。结论：反复梯度降压缺氧预激能明显增强小鼠心肌的缺氧耐全倍，该作用与反复缺氧预激促使机体各组织器官产生某些具有可转移性的保护性物质有关。This study was to explore effects of repetitive hypoxic preconditioning on the myocardialtolerance to hyposia of mice and its possible mechanism. [METHODS] Used normal mice and the mice precon-ditioned by grade-declined hyposia for five times to prepare plasm and myocardial homogenate respectively, theninjected plasm from normal and preconditioned mice P. I. into two groups of normal mice (Non-PP group andPP group) respectively, injected homogenate from normal and precoditioned mice P. I. into two other groups ofnormal drice (Non - PH group and PH group) respectively, and observed the change of cardial electron aetiva-tion time (CEAT)30ndn after injection under the air pressure of 28. 7KPa. [RESULTS] The CEAT of PHgroup and PP group increased up to 1. 8 - fold and 1. 29 - fold respectively compared with the correspondingNon- PH group and Non - PP group. [CONCLUTION] Repetitive hmpic prmnditioning under grade-declined air pressure can improve the myocardial tolerance to hypoxic of mice. The possible mechanisms mightbe that repetitive hypoxia preconditioning make heart produce some adaptive changes and some protective andtransferable materials.

关 键 词：梯度降压 缺氧预激 CEAT 小鼠 心肌缺血 

分 类 号：R542.2[医药卫生—心血管疾病]