黄芪当归对肾病鼠蛋白质合成代谢影响的研究  

Effect of Chinese Herbs on Anabolism of Protein in Nephrotic Rats

作　　者：陈孟华[1,2] 李丽英[1,2] 潘缉圣 王海燕[1,2] 

机构地区：[1]宁夏医学院附属医院肾脏内科 [2]北京医科大学第一医院肾病研究所

出　　处：《宁夏医学院学报》1999年第1期4-6,共3页Journal of Ningxia Medical College

摘　　要：目的：探讨黄芪当归改善肾病鼠蛋白质代谢紊乱的机制。方法：采用分子杂交的方法观察了肾病综合征大鼠肝白蛋白ｍＲＡＮ的表达。结果：肾病未用药组肝白蛋白ｍＲＮＡ表达（３２．０９±３．２３）较正常对照组（１６．６７±１．８）显著升高（Ｐ＜００１）；在肾病鼠中，与肾病未用药组比，黄芪当归治疗组的肝白蛋白ｍＲＮＡ表达（４４．７９±０．５１）显著升高（Ｐ＜００５），单味黄芪及黄芪的３个单组分治疗的各组大鼠肝白蛋白ｍＲＮＡ表达无显著差异（Ｐ＞００５）。结论：黄芪当归合剂可以增加肾病鼠肝白蛋白ｍＲＮＡ的水平，促进肝白蛋白的合成，改善肾病鼠蛋白质代谢紊乱。Objective:To investigate the mechanism of effect of Chinese herbs (Astragali As and Angelica An) on anabolism of protein in nephrotic rats.Methods:Liver albumin mRNA was detected by Northern Blot hybridization.Results:(1)Liver albumin mRNA of untreated nephrotic rats was significantly higher than the normal control rats ( P <0 01); (2) Liver albumin mRNA was significantly higher in nephrotic rats treated with As and An than untreated nephrotic rats ( P <0 05);But the level of albumin mRNA in other therapy group rats was of on change compared with untreated nephrotic rats ( P >0 05).Conclusion:Herb As and An can increase liver albumin mRNA and protein expression in nephrotic rats.

关 键 词：肾病综合征 基因表达 中医药疗法 黄芪 当归 

分 类 号：R277.52[医药卫生—中医学]