皮肤变应性结节性血管炎1100例分析  

Study on 1100 Cases of Cutaneous Allergic Nodular Vasculitis

作　　者：黄正吉[1] 石慧莉[1] 余碧娥[1] 杨国亮 

机构地区：[1]上海医科大学华山医院皮肤科,200040

出　　处：《中华皮肤科杂志》1999年第1期31-33,共3页Chinese Journal of Dermatology

摘　　要：目的研究复杂的小腿结节损害疾病。方法应用临床、组织病理、免疫学及免疫组织化学和血液学检查等。结果女性发病多于男性(6 09∶1) ,主要发生在21～50岁(73 36 %) ;临床表现以下肢皮下结节损害为主 ;疾病发作与缓解似与季节有关。组织病理学改变 :病变限于真皮乳突下层和皮下脂肪组织内 ,血管炎、液化性坏死和肉芽肿与肉芽肿样结构是其基本病变 ;毛细血管和细血管全部受累 ,内皮细胞增生为一显著特征 ;以淋巴细胞和组织细胞浸润为主 ;皮下脂肪间隔内为一般性炎症 ,表皮细胞正常。结论认为系一临床独立疾病 ,发病机理可能与延迟性超敏反应有关 。Objective To study a group of patients with inflammatory nodular lesions of the legs Methods The haematological, histopathological, immunological and immunohistochemical data and methods were used Results (1) The incidence was higher in the females than that in the males (6 09:1) (2) The onset of the disease was mainly at 21～50 years old (73 36%) (3) The predominant clinical feature was subcutaneous nodular lesions of the lower extremities (4) The attacks and remissions of the disease seemed to be influenced by the seasons (5) The histopathologic changes limited in the subpapillary layer and subcutaneous tissue (6) The essential findings consisted of vasculitis, liquefaction necrosis or granuloma and granuloma like structure (7) The capillaries and venules were affected in all patients and the proliferation of endothelial cells was marked feature (8) The inflammatory infiltrates were predominantly composed of lymphocytes and histiocytes (9) The fibrous septa of the subcutaneous tissue showed nonspecific inflammation, whereas, the dermal papillae and the epidermal cells were normal Conclusion It is the authors' opinion that the disease is a distinct clinical entity, cutaneous allergic nodular vasculitis, and the mechanism might be related to delayed hypersensitivity

关 键 词：血管炎 变应性皮肤 结节性 小腿 

分 类 号：R543[医药卫生—心血管疾病] R758.2[医药卫生—内科学]