硒暴露水平与农村老年人认知能力关系的研究  

Study on selenium exposure level related to cognitive function in rural elderly people

作　　者：程义斌[1] 金银龙[1] 马凤[1] 梁超轲[1] 刘娅[1] 边建朝 李萍[3] 高素娟[4] 

机构地区：[1]中国疾病预防控制中心环境与健康相关产品安全所,北京100050 [2]山东省地方病研究所 [3]四川省疾病预防控制中心 [4]美国印第安纳大学

出　　处：《卫生研究》2010年第4期483-485,490,共4页Journal of Hygiene Research

基　　金：美国NIH(No.R01AG19181-01A2)

摘　　要：目的了解硒(Se)暴露水平与农村老年人认知能力的关系以及影响因素。方法对200名农村老年人进行膳食问卷调查和6项认知能力调查,采集当地环境样品、食物样品以及研究对象的指甲和血样,采用2,3-二氨基萘荧光法测定样品中硒含量,结合膳食和问卷调查结果,综合考虑可能影响老年认知能力影响因素。结果不同Se暴露指标间均有很好的相关性,在综合考虑了年龄、受教育情况、APOE基因型等因素后,膳食Se摄入量和血Se含量水平的减少与老年认知能力的下降有显著性正相关关系(P<0.001)。结论老年认知能力的降低可能与Se暴露水平的降低有关。Objective To know the relationship between selenium exposure level and cognitive function and its influencing factors in rural elderly people.Methods A cross-sectional survey of 200 local rural elderly people were conducted by using dietary questionnaire and six cognitive questionnaires.The local environment samples were collected including food and nail and blood sample of study individuals.The trace amount of selenium were determined with 2,3-diaminonaphthalenet fluorometric determination.Multiple stepwise regression was used to examine the association between selenium exposure level and the composite Z score adjusting for age,gender, education,and other factors that might influence the cognitive scores.Results There were significant positively relationships between three selenium exposure indexes.The results showed that food selenium intake level and blood selenium level could significantly affected the Z score after adjusting age,education and other factors by using multiple stepwise regression analysis（ P〈0.001）.Conclusion Lower selenium exposure level maybe associated with lower cognitive function in rural elderly people.

关 键 词：硒 老年认知能力 老年人 

分 类 号：R592[医药卫生—老年医学] Q581[医药卫生—内科学]