超声波辅助强酸性阳离子交换树脂催化合成乙酰水杨酸的研究  

Synthesis of acetylsaicylic acid catalyzed by strong acidic cationic exchange resin under ultrasound irradiation

作　　者：刘小玲[1] 

机构地区：[1]广东梅州嘉应学院化学与环境学院,广东梅州514015

出　　处：《应用化工》2010年第7期1045-1047,共3页Applied Chemical Industry

摘　　要：用强酸性阳离子交换树脂为催化剂,以水杨酸和乙酸酐为反应原料,通过超声波辐射加热快速合成了乙酰水杨酸。最佳合成条件为：原料摩尔比乙酸酐∶水杨酸=3∶1,超声频率59 Hz,辐射时间25 min,反应温度70-75℃,催化剂用量0.5 g,产率达到92%,催化剂重复5次后仍然达到很高的产率。该法反应时间短,操作简单,催化剂可重复利用,环境友好,节约能源。Acetylsaicylic acid is synthesized under ultrasound irradiation using salicylic and acetic acid anhydride as raw materials and catalyzed by strong acidic cationic exchang resin.The optimum reaction conditions are as follows：molar ratio of acetic acid anhydride to salicylic acid is 3 ∶1,and the irradiation frequency is 59 Hz,the irradiation time is 25 min,the temperature 70～75 ℃,the catalyst 0.5 g,the yield was over 92%.The catalyst retains its activity after reuse 5 times.The main advances of this methodology are short reaction time,high yield,convenient manipulation and eco-friendly environment.

关 键 词：乙酰水杨酸 合成 超声辐射 强酸性阳离子交换树脂 

分 类 号：O625.54[理学—有机化学]