头孢呋辛钠与头孢克肟序贯治疗儿科感染成本效益分析  

Cost-effect analysis to step-down therapy with Cefuroxime Sodium and Cefixime Granules treatment for children infection

作　　者：郁冬梅[1] 吴家鸣[1] 郁惠东[1] 

机构地区：[1]江苏省启东市人民医院,江苏启东226200

出　　处：《吉林医学》2010年第22期3646-3648,共3页Jilin Medical Journal

摘　　要：目的:对头孢呋辛钠与头孢克肟序贯治疗儿科感染进行成本效益分析。方法:采用开放式对照的研究方法,将51例中度感染患儿分三组:头孢呋辛钠、头孢克肟序贯治疗组,静脉用头孢呋辛钠组和口服头孢克肟组。从药品经济学角度对临床疗效、安全性和医疗费用进行综合评价。结果:三组疗效比较,差异无统计学意义(P>0.05)。口服用药最经济,头孢呋辛钠、头孢克肟序贯治疗显示较高的成本效益,采用序贯治疗对门诊治疗患儿每天可节省费用56元,住院患儿每天可节省费用59元。结论:头孢呋辛钠、头孢克肟序贯治疗儿科中度感染有明显成本效益优势。头孢克肟疗效可靠,治疗费用低,是头孢序贯治疗的较理想的口服接续药。序贯治疗是值得提倡的方法。Objective To do a cost-effect analysis to step-down therapy with oral Cefixime Granules as after Cefuroxime Sodium treatment for children infection.Method Step-down therapy with oral Cefixime Granules was compared with parenteral Cefuroxime Sodium therapy in a open-randomized comparative trial of children with middle-serious bacterial infections.Patients were allocated to three treatment groups： ①intravenous group,patients received Cefuroxime Sodium treatment 7 ～ 10 days;②step-down group,patient received Cefuroxime Sodium for 2 ～ 3 days,then oral Cefixime Granules 9 mg/（kg·d） total 7 ～ 10 days;③oral group,chirldren received Cefixime Granules 9 mg/（kg·d） treatment for 7 ～ 10 days.Results A total of 51 patients were included in three group,overall clinical cure rates in three groups were same.Step-down treatment with oral Cefixime Granules was a cost-effective therapy,through cost-effect analysis.56 RMB can been saved in walk-in patient and 59 RMB in a hospitalized patient to intravenus cephalosporin every day （P 0.01） .Conclusion Step-down Cefuroxime Sodium and Cefixime Granules treatment in middle-serious bacterial infection has superiority in cost-effect analysis.The patient has a good life-quality in treatment period.Of course oral Cefixime Granules is a good selection with cost-effect to middle bacterial infection.

关 键 词：药品经济学 成本效益分析 抗生素 儿童 

分 类 号：R725.1[医药卫生—儿科]