地塞米松联合低分子右旋糖苷对ARDS兔模型血清IL-17、IL-23表达的影响  

Effect of Dexamethasone plus Dextran -40 to the Serum Level ofIL - 17, IL - 23 in ARDS Rabbit Model

作　　者：彭森[1] 肖红霞[2] 

机构地区：[1]广州军区武汉总医院急诊科,湖北武汉430070 [2]武汉大学校医院,湖北武汉430072

出　　处：《医学新知》2010年第3期163-166,共4页New Medicine

摘　　要：目的观察地塞米松、低分子右旋糖苷、地塞米松＋低分子右旋糖苷对急性呼吸窘迫综合征（ARDS）模型兔血清IL—17、IL－23表达的影响。方法50只日本大耳兔随机分为空白组、模型组、地塞米松（地米）组、低分子右旋糖苷（低右）组、地米＋低右组，每组10只。除空白组外，各组均制成ARDS模型，然后分别给予对应药物干预；干预后行血气分析，检测血清中IL－17、IL－23含量。结果模型组、地米组、低右组、地米＋低右组血氧分压均显著低于空白组，血清IL—17、IL－23浓度高于空白组；地米组、地米＋低右组血氧分压均高于模型组，血清IL－17、IL－23浓度均低于模型组；低右组血氧分压略高于模型组，差异无显著性；地米组、低右组、地米＋低右组三组比较，地米＋低右组血氧分压高于地米组，血清IL－17、IL－23浓度低于地米组；地米组血氧分压高于低右组，血清IL－17、IL－23浓度低于低右组。结论单纯低分子右旋糖苷治疗ARDS兔模型无显著性效果，地米＋低右治疗ARDS兔模型优于单纯地塞米松治疗效果，地塞米松和低分子右旋糖苷合用可能有协同作用。Objective To observe the serum level of IL - 17, IL -23 in ARDS rabbit model, evaluate the intervention effect of dexamethasone plus dextran - 40. Methods 50 rabbits were randomly divided into 5 groups ： control group, model group, dexamethasone group, dextran - 40 - group, dexamethasone plus dextran - 40 group, each group with 10 animals. Model group and dexamethasone group, dextran -40 group, dexamethasone plus dextran -40 group were injected with oleic acid by femoral vein to induce the ARDS rabbit model. Dexamethasone group, dextran -40 group, dexamethasone plus dextran - 40 group were given the intervention of dexamethasone, dextran - 40, dexametha- sone plus dextran -40 respectively. The blood was draw from femoral artery to detect the oxygen partial pressure and serum levels of IL - 17,IL - 23. Results The oxygen partial pressure of the model group were significantly lower in the model group,dexamethasone group,dextran-40- group,dexamethasone plus dextran- 40 group than the control group, but the serum level of IL - 17, IL - 23 was higher than the control group ; The dexamethasone group and dexam- ethasone plus dextran -40 group were higher than the model group in the blood oxygen partial pressure and the serum level of IL- 17 ,IL- 23; the dextran -40 group has a slightly higher than model group in the blood oxygen partial pressure,but the difference was not statistically significant; Compare among the dexamethasone group, dextran- 40 group and dexamethasone plus dextran -40 group, the blood oxygen partial pressure of dexamethasone plus dextran - 40 group was higher than dexamethasone group, the serum levels of L - 17, IL -23 was lower in the dexamethasone plus dextran -40group than the dexamethasone group; the blood oxygen partial pressure of the dexamethasone group was higher than the dextran -40 group, the serum levels of L - 17, IL -23 in the dexamethasone group was lower than the dextran - 40 group. Conclusion Dextran - 40 had no effect in treatment of ARDS rabbit model, but dexametha- sone plus dex

关 键 词：IL-17 IL-23 地塞米松 低分子右旋糖苷 

分 类 号：R563.8[医药卫生—呼吸系统]