新生儿高胆红素血症的远期随访研究  

A long-term follow-up of newborn infants with hyperbilirubinemia

作　　者：董淑兰[1,2,3] 华青[1,2,3] 于爱华 杨玉英 张玉英 

机构地区：[1]青岛医学院附属医院 [2]青岛市南区人民医院 [3]临沂市兰山区第一人民医院

出　　处：《中国实用儿科杂志》1999年第2期87-88,共2页Chinese Journal of Practical Pediatrics

摘　　要：目的探讨新生儿期血清胆红素水平和对远期预后的影响。方法对１２０例高胆红素血症患儿在５～１０岁时进行智力、听力及神经系统随访检查。结果３１例患儿有程度不等的智力缺陷，２５例有听力损失，５例有神经系统的改变。智力、听力及神经系统异常率与血清总胆红素峰值无显著相关性（Ｐ＞００５）。溶血组与非溶血组间异常率无显著性差异（Ｐ＞００５）。结论除重度高胆红素血症外，轻中度高胆红素血症（无论是否溶血）也可对新生儿产生永久性神经损害，致精神神经发育异常，仅凭血清总胆红素水平并不能确切预测远期预后。对所有高胆红素血症新生儿均应积极治疗，尽量减少后遗症的发生。Objective To study the effect of serum bilirubin level on long-term prognosis in neonates with hyperbilirubinemia.Methods 120 cases with hyperbilirubinemia were surveyed.All cases 5～10 years old were examined in intelligence intelligence,hearing and nervous system.Results 31 cases had intelligence deficiency at different degree,25 cases had hearing loss and 5 cases had abnormality in nervous system.There wasn't obvious correlation between abnormal rate in intelligence,hearing and nervous system and the peak value of total bilirubin(P>0 05).And there wasn't significant difference between the abnormal rate of hemolysis group and nonhemolytic group(P>0 05).Conclusion Mild,moderate,and severe hyperbilirubinemia(whether hemolytic or not) will produce permanent nervous impairment in neonates and cause psychoneurotic abnormality.Long-term prognosis couldn't be exactly predicted merely depending on the total level of bilirubin.All neonates with hyperbilirubinemia must be actively treated to reduce sequel to the minimum.

关 键 词：新生儿 高胆红素血症 智力 听力 远期随访 

分 类 号：R722.17[医药卫生—儿科]