纳米二氧化钛和纳米氧化锌的Ames试验  

Ames test of nano TiO_2 and nano ZnO

作　　者：马茂才[1] 黄萍[1] 晏辉 陶云[1] 邓雅斌[1] 李东辉[1] 

机构地区：[1]厦门大学医学院抗癌研究中心,福建厦门361005 [2]广州市海珠区人民医院,广东广州510220

出　　处：《癌变．畸变．突变》2010年第4期302-304,共3页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：国家自然科学基金项目(90206016);福建省科技重点项目(2001H045)

摘　　要：目的:研究纳米二氧化钛、纳米氧化锌两种纳米光催化材料的潜在致突变性。方法:采用Ames试验平板掺入法,计数TA97,TA98,TA100,TA102四种菌株分别在纳米二氧化钛及纳米氧化锌5个不同浓度下的回变菌落数。结果:纳米二氧化钛、纳米氧化锌材料各剂量组均未引起测试菌株回变菌落数的明显增加。Ames试验结果均为阴性。结论:纳米二氧化钛、纳米氧化锌在实验剂量范围内未见致突变性。OBJECTIVE：To study the potential mutagenicity of two photocatalytic nanomaterials,nano TiO2 and nano ZnO.METHODS：In the plate incorporation test of Salmonella typhimurium,the average colony number of spontaneous revertants of TA97,TA98,TA100,TA102 were set at 5 concentrations.RESULTS：The colony number of revertants for the materials tested did not increase with statistical significance,compared with that of spontaneous revertants.The results of Ames test for the two kinds of nanoparticle were negative.CONCLUSION：The results imply that the two kinds photocatalytic nanomaterials tested did not show potential mutagenicity.

关 键 词：纳米光催化材料 AMES试验 致突变性 纳米二氧化钛 纳米氧化锌 

分 类 号：R994.3[医药卫生—毒理学]