双料喉风散抗炎和抗氧化活性的研究  

The anti-inflammatory effect and anti-oxidant activities of Shuangliao Houfeng San

作　　者：陈一村[1] 唐昭 蔡聪艺[1] 秦永洁[1] 

机构地区：[1]汕头大学医学院药理学教研室,广东汕头515041 [2]广东省梅州嘉应制药有限公司,广东梅州514000

出　　处：《癌变．畸变．突变》2010年第4期305-307,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：目的:研究双料喉风散对巴豆油引起小鼠耳肿胀的抑制作用和抗氧化活性。方法:昆明小鼠随机分为正常对照组、模型组和药物组,用巴豆油对小鼠耳片致炎,测定药物对耳肿胀程度的抑制率,评价双料喉风散的整体抗炎活性;并研究双料喉风散对致炎的耳组织中炎症细胞一氧化氮(NO)释放的影响。通过研究双料喉风散对小鼠血清中丙二醛(MDA)和超氧化物歧化酶(SOD)的影响,评价双料喉风散的抗氧化活性。结果:与模型组相比,双料喉风散(200、400和800mg/kg)能明显减少巴豆油引起的小鼠耳肿胀(P<0.05);能明显降低肿胀耳组织中NO的含量(P<0.05)。双料喉风散能减少血清MDA的生成,提高血清SOD的活力。结论:双料喉风散对巴豆油引起小鼠耳肿胀具有抑制作用,同时具有较强的抗氧化活性。OBJECTIVE：This study was undertaken to ascertain the anti-inflammatory properties and antioxidant activities of Shuangliao Houfeng San（SHS）.METHODS：Kunming mice were randomly divided into the control group,model group,and different concentration SHS groups.The anti-inflammatory effect of SHS was evaluated with croton oil-induced ear edema in mice and the increased levels of inflammatory mediators,nitric oxide（NO）.The antioxidant activities were also studied on the effect on malondialdehyde（MDA）levels and enhancement of superoxide dismutase（SOD）activities.RESULTS：SHS produced significant inhibition on croton oil-induced ear edema in mice in a dose-dependent manner.SHS reduced the levels of NO and MDA,and enhanced the activities of SOD.CONCLUSION：SHS possesses potent anti-inflammatory properties and antioxidant activity.

关 键 词：双料喉风散 抗炎 抗氧化 一氧化氮 超氧化物歧化酶 丙二醛 

分 类 号：R962[医药卫生—药理学]