血清透明质酸、IV型胶原及层连蛋白检测的临床应用研究  

Chang of Concentrations of Serum Hyaluronic Acid,Collage Type IV and Laminin in patients with Chronic Hepatitis B

作　　者：郝菁华[1] 邹建文[1] 高鹏[1] 石军[1] 朱菊人[1] 

机构地区：[1]山东省立医院

出　　处：《山东医药》1999年第3期1-2,共2页Shandong Medical Journal

摘　　要：用放免法检测３９例慢性乙型肝炎（下称慢乙肝）、４例慢乙肝肝硬化患者及１９例健康人肘血清透明质酸（ＨＡ）、ＩＶ型胶原（ＩＶ·Ｃ）和层连蛋白（ＬＮ）水平。结果表明，ＩＶ·Ｃ在轻度肝炎时即显著升高，较ＨＡ、ＬＮ灵敏；ＨＡ、ＩＶ·Ｃ和ＬＮ均与肝纤维化程度呈正相关，相关系数分别为０．６６７、０．７５７和０．４８６；单项检测以ＩＶ·Ｃ为最好，其对肝纤维化诊断的灵敏度、特异度、准确度分别为６２．５０％、５７．１４％、６１．２９％；血清ＨＡ水平升高还与门脉高压征关系密切（Ｐ＜０．００１）。Serum hyaluronic acid(HA)、Collage type IV(IV·C)and laminin(LN)levels were determined by RIA in 39 patients with chronic hepatitis B,4 patients with hepato cirrhosis and 19 healthy persons Results:Serum IV·C level was significantly increased even in patients with mild hepatitis,and it was more sensitive than HA and LN Concentrations of serum HA、IV·C and LN all were significantly correlated with the degree of liver fibrosis,and the correlation coefficient were 0 667、0 757 and 0 486 respectively IV·C was the best marker in diagnosis of liver fibrosis,and its sensitivity,speciality,accuracy were 62 5%,57 14%and 61 29% respectively The increase of serum HA level was also related to portal hypertension(P<0 001)

关 键 词：透明质酸 IV型胶原 层连蛋白 乙型肝炎 

分 类 号：R512.620.4[医药卫生—内科学]