2350例艾滋病患者血液培养病原体和药敏结果分析  

Analysis of the Blood-cultivated Pathogen and Drug-sensitivity from 2350 Cases of AIDS Patients

作　　者：唐秀文 张晶[2] 

机构地区：[1]广西壮族自治区龙潭医院检验科,柳州市545005 [2]广西壮族自治区南溪山医院检验科,桂林市541002

出　　处：《广西医学》2010年第7期782-785,共4页Guangxi Medical Journal

基　　金：广西医药卫生科学研究基金(桂卫科Z2007029)

摘　　要：目的探讨艾滋病(AIDS)患者机会性感染的病原体种类和药敏结果。方法采用BecT/Alert3D血培养仪进行细菌培养;细菌和真菌鉴定采用API系统,药敏采用ATB药敏条。结果 2350例患者血培养阳性率为25.3%,其中马尔尼菲青霉菌为18.6%,新生隐球酵母菌为2.2%,葡萄球菌属为2.1%,沙门氏菌属为1.0%,马红球菌为0.6%,大肠埃希菌为0.4%等。52株新生隐球酵母菌对5种抗真菌药物均敏感,有24.0%葡萄球菌产耐甲氧西林菌株,20.0%大肠埃希菌产超广谱β-内酰胺酶(ESBL)。其他菌株为低毒株或无毒株。结论 AIDS患者发生机会性感染病原体以真菌占优势,尤其是马尔尼菲青霉菌;多数菌株药物敏感试验结果敏感;警觉罕见的病原体引起感染。Objective To investigate the categories of AIDS opportunistic infection pathogens and the result of drug sensitivity.Methods All the blood samples were cultured by BecT/Alert 3D culture system,and the bacteria andfungi were identified by API system,the susceptibility was tested by ATB drug-sensitive strip.Results The positive rate of cultivated blood specimens was 25.3%,of which Penicillium marneffei was 18.6%,Newborn Crytococcus yeast 2.2%,Staphylococcus 2.1%,Salmonella 1.0%,MA Hong-ball 0.6%,Escherichia coli 0.4% and so on.Newborn Crytococcus yeast had not yet appeared to have drug resistance in five kinds of drug sensitive experiments.27.6% of Staphylococcus produces Methicillin-resistant strains and 20.0% of Escherichia coli produced ESBL.The other strains were sensitive.Conclusion Fungus,especially Penicillium marneffei,is the dominant pathogens of AIDS opportunistic infection.Most strains are low poisonous or non-toxic in the results of drug sensitive experiments.We should paid attention to infection which caused by rare virus.

关 键 词：艾滋病 机会性感染 病原体 药敏试验 

分 类 号：R446.5[医药卫生—诊断学] R512.91[医药卫生—临床医学]