MAO基因遗传多态性及与精神疾病相关性研究进展  

Polymorphisms of monoamine oxidase gene and its correlation with certain psychiatric disorders

作　　者：张璐[1] 王保捷[1] 丁梅[1] 庞灏[1] 张津京[1] 

机构地区：[1]中国医科大学法医学院,辽宁沈阳110001

出　　处：《中国法医学杂志》2010年第4期255-258,共4页Chinese Journal of Forensic Medicine

基　　金：辽宁省教育厅高等学校科研计划项目(2004D052)

摘　　要：单胺氧化酶(monoamine oxidase,MAO)是调控儿茶酚胺和5-羟色胺等单胺类氧化脱氨的一类重要酶,广泛分布于包括神经系统在内的人体各种组织中,具有多种生物学功能。MAO有两种类型,MAO-A和MAO-B。MAO基因具有遗传多态性,其中部分多态性位点与某些精神疾病如严重抑郁障碍、酒精中毒、反社会情感障碍及精神分裂症等有一定的相关性。MAO基因遗传多态性的研究,可能为法医学个人识别与亲权鉴定提供新的遗传标记,并为司法精神病鉴定提供参考性遗传学指标。Monoamine oxidase（MAO） is a kind of mitochondrial outer membrane enzyme that degrades biogenic amines,such as catecholamine and serotonin.It has a variety of biological functions,and can be found in various human tissues,including nervous system.Two MAO enzymes,MAO-A and MAO-B have been identified.MAO gene has polymorphisms,and some of which have a close relationship with certain psychic diseases,such as major depression,alcoholism,antisocial personality disorder and so on.MAO gene can acts as a new forensic individual identification and parentage testing genetic marker or legal psychiatry testing referential genetic marker.

关 键 词：法医精神病学 单胺氧化酶 多态性 精神疾病 个人识别 

分 类 号：D919.8[医药卫生—法医学]